Consolidation & Interference in Multiple Sclerosis

NCT ID: NCT02081508

Last Updated: 2016-08-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 39 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-03-31
• Study Completion Date: 2015-05-31

Brief Summary

The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.

Detailed Description

The ability to form new long-lasting memories is important for successful independent living and a high quality of life. Roughly half of the individuals diagnosed with Multiple Sclerosis (MS) have difficulty remembering new information and this is likely associated with poor acquisition of new information. There are only a limited number of studies that have investigated memory consolidation in MS. The current study will investigate the role of interference during the consolidation time period of memory formation.

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Unfilled interference

Interference onset: delayed test at 540000 ms

Group Type: EXPERIMENTAL

Interference onset

Intervention Type: BEHAVIORAL

Temporal duration of interference onset.

Early interference

Interference onset: delayed test at 0 ms

Group Type: EXPERIMENTAL

Interference onset

Intervention Type: BEHAVIORAL

Temporal duration of interference onset.

Mid interference

Interference onset: delayed test at 360000 ms

Group Type: EXPERIMENTAL

Interference onset

Intervention Type: BEHAVIORAL

Temporal duration of interference onset.

Late interference

Interference onset: delayed test at 180000 ms

Group Type: EXPERIMENTAL

Interference onset

Intervention Type: BEHAVIORAL

Temporal duration of interference onset.

Interventions

Interference onset

Temporal duration of interference onset.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• If you are between the ages of 18-65.
• If you have a diagnosis of Multiple Sclerosis (MS) or are medically healthy.
• If you have MS, you have not had a flare up of MS symptoms in the past month.
• You do not have other neurological issues such as, Epilepsy or Stroke.
• You do not have a significant history of psychiatric problems or a current diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder .
• You do not have a significant history of drug or alcohol abuse.
• You can read and speak English fluently.
• You are not currently taking steroids.

Exclusion Criteria

• You are younger than 18 years old.
• You are older than 65 years old.
• You have had a prior stroke or neurological disease other than MS.
• You have a history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder, Bipolar Disorder.
• You have a significant alcohol or drug abuse history.
• You are currently taking steroids.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kessler Foundation

OTHER

Sponsor Role: lead

Responsible Party

Joshua Sandry

Visiting Scientist Neuropsychology & Neuroscience Research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Kessler Foundation

West Orange, New Jersey, United States

Countries

United States

Other Identifiers

R-800-13

Identifier Type: -

Identifier Source: org_study_id