Latent Tuberculosis in Second Generation Immigrants From High Risk Countries Compare to Low-risk Young Israeli Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

115 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2018-11-30

Brief Summary

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The aim of study is to evaluate the prevalence of latent TB in second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member who was born in a country with high incidence of tuberculosis. Using study questionnaire IGRA and tuberculin skin test the investigators expect that the second generation immigrants group will have more positive IGRA test than the control native group.

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Detailed Description

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Conditions

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Latent Tuberculosis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Investigators

Study Groups

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Second generation immigrants from high TB incidence countries

Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA).

Group Type OTHER

Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)

Intervention Type PROCEDURE

Native Israelis

Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA).

Group Type OTHER

Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)

Intervention Type PROCEDURE

Interventions

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Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age 18-25
* Men and women
* Second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000).
* Native Israelis without a family member who was born in a country with high incidence of tuberculosis.

Exclusion Criteria

* Prior contact with a tuberculosis patient
* Working (more than a month) in high risk setting such as health care workers, working with immigrants from countries with high incidence of tuberculosis.
* HIV infection and any immunodeficiency condition.
* Recent live-virus vaccination
* Acute infectious disease
* Prior serious reaction to tuberculin skin test
* Pregnancy

Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes