Safety and Efficacy Study of CLS001Topical Gel Compared to Vehicle in Subjects With Inflammatory Acne Vulgaris

NCT ID: NCT02066545

Last Updated: 2015-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

327 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Brief Summary

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The primary objective of this study is to evaluate the safety and efficacy of once-daily topical application of CLS001 1%, 1.75% and 2.5% topical gel compared to vehicle topical gel in subjects with inflammatory acne vulgaris

Detailed Description

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Conditions

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Acne Vulgaris

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Vehicle Gel

Group Type PLACEBO_COMPARATOR

CLS001 Topical Gel Vehicle

Intervention Type DRUG

CLS001 topical gel 1%

Topical application once daily

Group Type EXPERIMENTAL

CLS001 Topical Gel

Intervention Type DRUG

CLS001 topical gel 1.75%

Topical application once daily

Group Type EXPERIMENTAL

CLS001 Topical Gel

Intervention Type DRUG

CLS001 topical gel 2.5%

Topical application once daily

Group Type EXPERIMENTAL

CLS001 Topical Gel

Intervention Type DRUG

Interventions

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CLS001 Topical Gel

Intervention Type DRUG

CLS001 Topical Gel Vehicle

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or non-pregnant female subjects with facial acne vulgaris, 12 years of age or older.
* Subjects with ≥20 inflammatory facial lesions (papules, pustules) inclusive of the nose, with a maximum of 9 inflammatory pustules.
* An Investigator's Global Assessment (IGA) of Moderate (3) or Severe (4)

Exclusion Criteria

* Subjects with acne conglobate, acne fulminans, and secondary acne (chloracne, drug-induced acne, polycystic ovarian syndrome, etc.)
* Subjects with greater that 75 facial non-inflammatory lesions (open and/or closed comedones; excluding the nose)
* Subjects with more than 2 facial nodulocystic lesions
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Maruho Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Encino Research Center

Encino, California, United States

Site Status

Skin Surgery Medical Group, Inc.

San Diego, California, United States

Site Status

Clinical Science Institute

Santa Monica, California, United States

Site Status

Skin Care Research, Inc.

Boca Raton, Florida, United States

Site Status

Belleair Research Center

Pinellas Park, Florida, United States

Site Status

Moore Clinical Research, Inc.

Tampa, Florida, United States

Site Status

Kenneth R. Beer, MD, PA

West Palm Beach, Florida, United States

Site Status

MedaPhase, Inc.

Newnan, Georgia, United States

Site Status

Hamzavi Dermatology

Fort Gratiot, Michigan, United States

Site Status

Minnesota Clinical Study Center

Fridley, Minnesota, United States

Site Status

Academic Dermatology Associates

Albuquerque, New Mexico, United States

Site Status

Manhattan Dermatology & Cosmetic Center

New York, New York, United States

Site Status

Derm Research Center of New York, Inc.

Stony Brook, New York, United States

Site Status

Dermatology Consulting Services

High Point, North Carolina, United States

Site Status

Wake Research Associates

Raleigh, North Carolina, United States

Site Status

Tennessee Clinical Research Center

Nashville, Tennessee, United States

Site Status

Premier Research

Austin, Texas, United States

Site Status

J & S Studies, Inc.

College Station, Texas, United States

Site Status

Progressive Clinical Research, PA

San Antonio, Texas, United States

Site Status

Premier Clinical Research

Spokane, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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CLS001-CO-PR-003

Identifier Type: -

Identifier Source: org_study_id

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