Determining the Specificity of High Definition Electrical Brain Stimulation Using Simultaneous Magnetoencephalography

NCT ID: NCT02060708

Last Updated: 2016-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2015-06-30

Brief Summary

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Non-invasive human brain stimulation using weak transcranial direct-current stimulation (tDCS) has been thousands of times in research studies over the past fifteen years as a therapy to help improve the effectiveness of repeated training sessions (e.g., hand exercises in the context of daily physiotherapy), due to its safety, tolerability, convenience and cost-effectiveness. tDCS works by temporarily enhancing brain activity during performance of a specific task, helping with learning and training.

The investigators will use magnetoencephalography (MEG) brain imaging to view the real-time effects of high definition (HD) tDCS on several brain areas involved in vision, hearing, movement, and memory. The investigators hypothesize that changing the task (auditory, visual or memory task) but keeping the position of the electrodes over the motor cortex will result in modulation of brain activity in only the central target motor area, and not on non-target temporal, occipital or pre-frontal areas.

Detailed Description

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Conditions

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Real HD-tDCS Sham HD-tDCS Visual Task Motor Task Auditory Task Working Memory Task

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Real HD-tDCS first, Sham HD-tDCS second

Real HD-tDCS will be applied in the first session Sham HD-tDCS will be applied in the second session (at least one week after the first session)

Group Type OTHER

HD-tDCS

Intervention Type DEVICE

HD-tDCS non-invasive brain stimulation using this same device (Soterix) has been designated a 'non-significant risk' by the US FDA.

Sham HD-tDCS first, Real HD-tDCS second

Sham HD-tDCS will be applied in the first session Real HD-tDCS will be applied in the second session (at least one week after the first session)

Group Type OTHER

HD-tDCS

Intervention Type DEVICE

HD-tDCS non-invasive brain stimulation using this same device (Soterix) has been designated a 'non-significant risk' by the US FDA.

Interventions

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HD-tDCS

HD-tDCS non-invasive brain stimulation using this same device (Soterix) has been designated a 'non-significant risk' by the US FDA.

Intervention Type DEVICE

Other Intervention Names

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High Definition Transcranial Direct Current Stimulation

Eligibility Criteria

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Inclusion Criteria

* Normal hearing and vision

Exclusion Criteria

* Current pregnancy
* Presence of metallic implants in the head
* Use of any medications
* Any history of mental health or neurological conditions
* Inability to perform any of the tasks for any reason
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Hospital for Sick Children

OTHER

Sponsor Role lead

Responsible Party

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Douglas Cheyne

Senior Scientist and Associate Professor, Diagnostic Imaging

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Hospital for Sick Children

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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1000042023

Identifier Type: -

Identifier Source: org_study_id

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