Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

56 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-15

Study Completion Date

2017-03-08

Brief Summary

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The primary objective of this study is to estimate the distribution of pathogenic species and genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and Assessment System) corresponding to the severity of dental caries among patients aged 3-45 years consulting in the Dentistry Departments of the Nîmes University Hospital and the Montpellier University Hospital.

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Detailed Description

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Secondary objectives include:

* Compare the distribution of bacterial species in relation to stages of severity of caries
* Compare the results from plaque with those of saliva samples.

Conditions

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Dental Cavity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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3 to 16 years of age

Volunteers of 3 to 16 years of age, coming in to the hospital for a dental consultation. See inclusion/exclusion criteria.

Intervention: Dental cavity evaluation Intervention: Saliva sampling Intervention: Plaque sampling

Dental cavity evaluation

Intervention Type OTHER

The dental cavities present will be evaluated using the ICDAS (International Caries Detection and Assessment System).

Saliva sampling

Intervention Type BIOLOGICAL

A saliva sample will be harvested.

Plaque sampling

Intervention Type BIOLOGICAL

Plaque samples from a healthy tooth and a tooth with a cavity will be harvested.

17 - 45 years of age

Volunteers of 17 to 45 years of age, coming in to the hospital for a dental consultation. See inclusion/exclusion criteria.

Intervention: Dental cavity evaluation Intervention: Saliva sampling Intervention: Plaque sampling

Dental cavity evaluation

Intervention Type OTHER

The dental cavities present will be evaluated using the ICDAS (International Caries Detection and Assessment System).

Saliva sampling

Intervention Type BIOLOGICAL

A saliva sample will be harvested.

Plaque sampling

Intervention Type BIOLOGICAL

Plaque samples from a healthy tooth and a tooth with a cavity will be harvested.

Interventions

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Dental cavity evaluation

The dental cavities present will be evaluated using the ICDAS (International Caries Detection and Assessment System).

Intervention Type OTHER

Saliva sampling

A saliva sample will be harvested.

Intervention Type BIOLOGICAL

Plaque sampling

Plaque samples from a healthy tooth and a tooth with a cavity will be harvested.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Volunteers aged 3 to 45 who come in to the hospital for a dental consultation
* Minors must have parental permission
* The patient must have given his/her informed and signed consent

Exclusion Criteria

* The patient is participating in another study
* The patient is in an exclusion period determined by a previous study
* The patient is pregnant, or breastfeeding
* The patient has been on antibiotics within the past two months
* Smokers
* Teeth under current care
* Parodontopathy
* Use of a mouthwash within the last week
* Insufficient numbers of healthy and/or teeth with carious lesions for carrying out the study

Minimum Eligible Age

3 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes