The Effectiveness of Co-packaging With Zinc to Improve Treatment of Diarrhea and Pneumonia in Guatemala

NCT ID: NCT02044107

Last Updated: 2014-01-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

320 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2014-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This project applies a randomized community design to test the effectiveness of health center level co-packaging and counseling messages to improve provider and caregiver behavior in the treatment of diarrhea with zinc \& oral rehydration salts (ORS) and treatment of pneumonia with zinc \& antibiotics in children aged 2-59 mo old. We will evaluate the adherence of caregivers in 10 health posts in 5 municipalities randomly assigned to receive the health center level co-packaging and counseling messages in addition to current standard care, by comparing them with the caregivers in 10 health posts in 5 municipalities randomly assigned to the receive only the current standard of care. Cost-effectiveness of co-packaging at the health-center level, as a means of improving provider treatment and counseling practices and caregiver adherence, will be evaluated.

The main objective is to establish the effectiveness of a facility level co-packaging and counseling messages for increasing the adherence by caregivers of children aged 2-59 mo old to the prescribed 10 day treatment with zinc to complement ORS for the treatment of diarrhea and zinc to complement the antibiotics for the treatment of pneumonia diagnosed and treated in public health posts.

Specific Quantitative Objectives:

• To determine if visible co-packaging with pre-tested counseling messages:

* Improves adherence of caregivers of children towards the prescribed zinc treatment.
* Improves knowledge, awareness or attitudes of caregivers of children and health providers at public health care centers towards the prescribed zinc treatment.
* Results in overall increase in health care-seeking for the treatment of diarrhea and pneumonia at public health care centers.

Specific Qualitative Objectives:

* To establish the perception, attitudes and experiences of caregivers towards the visible co-packaging with pre-tested counseling messages to promote the prescribed zinc treatment.
* To establish the perception, attitudes and experiences of health providers at public health care centers towards the visible co-packaging with pre-tested counseling messages to promote the prescribed zinc treatment.
* To establish the perception, attitudes and experiences of children aged 4 to 5 years old towards the visible co-packaging with pre-tested counseling messages to promote the prescribed zinc treatment.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Please note that the study protocol is also available in Spanish.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Diarrhea. Pneumonia.

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Co-packaging and counseling messages

Current standard care at public health center ( zinc ORS for treatment of diarrhea and antibiotics for treatment of of pneumonia).

The intervention consists of health center level co-packaging and visual counseling messages (zinc \& ORS packaged at health center for diarrhea, and zinc \& antibiotics co-packaged at health center for pneumonia) Co-packaging is done in a plastic bag, which is covered with pre-tested zinc treatment messages - a distinct packaging has been designed for diarrhea and for pneumonia

Group Type EXPERIMENTAL

Co-packaging and counseling messages

Intervention Type BEHAVIORAL

The intervention involves co-packaging in 2 distinct packages: 1) for diarrhea treatment to package zinc \& ORS for the treatment of diarrhea using a plastic bag with printed messages that were pre-tested in formative research; and 2) for pneumonia treatment to co-package zinc \& antibiotics in a plastic bag with printed messages that were pre-tested in a formative research phase. Pre-tested zinc treatment messages will be on posters displayed in the intervention health centers. Orientation will be provided to health facility staff in control and intervention areas.

Control group

Current standard care at public health center (zinc \& ORS for treatment of diarrhea and zinc \& antibiotics for treatment of of pneumonia).

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Co-packaging and counseling messages

The intervention involves co-packaging in 2 distinct packages: 1) for diarrhea treatment to package zinc \& ORS for the treatment of diarrhea using a plastic bag with printed messages that were pre-tested in formative research; and 2) for pneumonia treatment to co-package zinc \& antibiotics in a plastic bag with printed messages that were pre-tested in a formative research phase. Pre-tested zinc treatment messages will be on posters displayed in the intervention health centers. Orientation will be provided to health facility staff in control and intervention areas.

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

The physical co-packaging is called the "bolsita salva-vida"

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* The child is aged between between 2 and 59 mo old (\< 5 years old).
* The child is diagnosed with diarrhea or pneumonia at one of the selected public health care centers.
* The caregiver accompanying the child to the public health care centers must live in the same household.

Exclusion Criteria

* Unwillingness to sign consent form.
Minimum Eligible Age

2 Months

Maximum Eligible Age

59 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Micronutrient Initiative

OTHER

Sponsor Role collaborator

Center for Studies of Sensory Impairment, Aging and Metabolism

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Marieke Vossenaar

Senior Program Leader for Diet and Health

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Marion Roche, PhD

Role: STUDY_DIRECTOR

Micronutrient Initiative

María del Rosario García Meza, MA

Role: PRINCIPAL_INVESTIGATOR

Center for Studies of Sensory Impairment, Aging and Metabolism

Noel W Solomons, MD

Role: STUDY_CHAIR

Center for Studies of Sensory Impairment, Aging and Metabolism

Marieke Vossenaar, PhD

Role: PRINCIPAL_INVESTIGATOR

Center for Studies of Sensory Impairment, Aging and Metabolism

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Guatemala: Ministry of Public Health and Social Assistance

San Marcos, Departamento de San Marcos, Guatemala

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Guatemala

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Marieke Vossenaar, phD

Role: CONTACT

50259000045

María del Rosario García Meza, MA

Role: CONTACT

50254147956

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Marieke Vossenaar, PhD

Role: primary

50259000045

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CeSSIAM_01

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Therapeutic Zinc in Childhood Pneumonia
NCT00252304 COMPLETED PHASE2/PHASE3
Zinc and Pneumonia Protocol
NCT00133432 TERMINATED PHASE3