Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SPARC1316

NCT ID: NCT02041221

Last Updated: 2016-05-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Study Completion Date

2014-11-30

Brief Summary

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Sun Pharma Advanced Research company Limited has developed a dry powder inhaler of compound SPARC1316 for oral inhalation. This clinical study is a Phase I/IIa study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple ascending doses of S0597 administered by oral inhalation to healthy volunteers and asthma patients.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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SPARC1316 Dose 1

Subjects will be administered with SPARC1316 dose 1

Group Type EXPERIMENTAL

SPARC1316 Dose 1

Intervention Type DRUG

The subjects will receive SPARC1316.

Placebo

The subjects will receive placebo.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

SPARC1316 Dose 2

Subjects will be administered with SPARC1316 dose 2

Group Type EXPERIMENTAL

SPARC1316 Dose 2

Intervention Type DRUG

SPARC1316 Dose 3

Subjects will be administered with SPARC1316 dose 3

Group Type EXPERIMENTAL

SPARC1316 Dose 3

Intervention Type DRUG

SPARC1316 Dose 4

Subjects will be administered with SPARC1316 dose 4

Group Type EXPERIMENTAL

SPARC1316 Dose 4

Intervention Type DRUG

SPARC1316 Dose 5

Subjects will be administered with SPARC1316 dose 5

Group Type EXPERIMENTAL

SPARC1316 Dose 5

Intervention Type DRUG

Interventions

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SPARC1316 Dose 1

The subjects will receive SPARC1316.

Intervention Type DRUG

Placebo

Intervention Type DRUG

SPARC1316 Dose 2

Intervention Type DRUG

SPARC1316 Dose 3

Intervention Type DRUG

SPARC1316 Dose 4

Intervention Type DRUG

SPARC1316 Dose 5

Intervention Type DRUG

Other Intervention Names

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The subjects will receive a matching placebo by oral inhalation.

Eligibility Criteria

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Inclusion Criteria

* Subjects willing to provide informed consent
* Male or female subjects aged 18 to 65 years inclusive
* Body mass index (BMI) between 18.0 and 30.0 kg/m2 inclusive
* Non-smokers or ex-smokers

Exclusion Criteria

* Subjects with a supine systolic blood pressure ≥160 mmHg and/or a supine diastolic blood pressure ≥100 mmHg
* Subjects who have a significant infection or known inflammatory process on screening or admission.
* Subjects who are unlikely to co-operate with the requirements of the study.
* Positive serology for infectious disease (hepatitisB or C , HIV) at screening
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sun Pharma Advanced Research Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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SPARC study site

London, London, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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SPARC_Ltd_ CLR_13_16

Identifier Type: -

Identifier Source: org_study_id

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