Individualized Infiximab Dosing-Proof of Concept Study

NCT ID: NCT02027727

Last Updated: 2017-07-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

56 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-11-30

Study Completion Date

2018-03-31

Brief Summary

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The purpose of this study is to determine which early infliximab pharmacokinetic level is most associated with clinical remission at weeks 30 and 54 in pediatric IBD patients.

Detailed Description

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Our aims are:

1. to determine which early pk level; week 6 (peak), week 8 (2 week) or week 14 (trough), is most associated with week 30 and 54 outcomes in pediatric IBD patients.
2. to determine if the forecasted PK determined by a newly developed Population PK Model software program is in agreement with the observed PK in IBD patients receiving infliximab.

Subject recruitment is limited to patients of the principal investigator only. Subjects will be approached for participation in the research in person during a routine clinic visit by a member of the study team.

Conditions

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Inflammatory Bowel Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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No intervention

No intervention- this is an observational study of patients receiving Infliximab.

No Intervention

Intervention Type OTHER

no intervention- tihs is an observational study

Interventions

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No Intervention

no intervention- tihs is an observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Males and females on IFX
2. Patients with IBD
3. Age 6-23
4. Able to obtain consent

Exclusion Criteria

1. Not receiving infliximab
2. On 10 mg/kg of IFX
3. Not able to obtain consent
Minimum Eligible Age

6 Years

Maximum Eligible Age

23 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cedars-Sinai Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Namita Singh, M.D.

Attending Physician of Pediatrics IBD Center, Cedars Sinai Med Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Namita Singh, MD

Role: PRINCIPAL_INVESTIGATOR

Cedars-Sinai Medical Center

Locations

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Cedars Sinai Medical Center

Los Angeles, California, United States

Site Status

Countries

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United States

Other Identifiers

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Infiximab Dosing

Identifier Type: -

Identifier Source: org_study_id

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