Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
NCT ID: NCT02025023
Last Updated: 2020-02-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
120 participants
INTERVENTIONAL
2013-12-31
2026-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Incision and Curettage
A vertical incision over the area of chalazion will be done. Inflammatory material will be removed and the chalazion capsule will be excised.
Incision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Injection of Triamcinolone Acetonide
0.1 ml of triamcinolone is injected directly in the chalazion.
Triamcinolone Acetonide
If chalazion present at follow-up, another Triamcinolone injection will be done.
Incision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Injection of 5-fluorouracil
0.1 ml of 5-fluorouracil is injected directly in the lesion transconjunctivally.
5-fluorouracil Injection
If the chalazion is present at follow-up visit, another injection of 5-FU will be given.
Incision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Injection of triamcinolone/5FU mixture
0.1 ml of a 4:1 mixture of 4 parts 5-FU and 1 part triamcinolone is injected in the lesion.
Incision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Triamcinolone Acetonide/5-fluorouracil mixture
If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.
Interventions
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5-fluorouracil Injection
If the chalazion is present at follow-up visit, another injection of 5-FU will be given.
Triamcinolone Acetonide
If chalazion present at follow-up, another Triamcinolone injection will be done.
Incision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
Triamcinolone Acetonide/5-fluorouracil mixture
If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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University of Washington
OTHER
Responsible Party
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Matthew Zhang
Assistant Professor of Ophthalmology
Principal Investigators
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Matthew M Zhang, MD
Role: PRINCIPAL_INVESTIGATOR
University of Washington Eye Institute
Locations
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University of Washington Eye Institute at Harborview
Seattle, Washington, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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STUDY00003748
Identifier Type: -
Identifier Source: org_study_id
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