Single Dose of Atorvastatin and Circulating Endothelial Microparticles

NCT ID: NCT02023892

Last Updated: 2014-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Brief Summary

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Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

Detailed Description

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Conditions

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Endothelium Hydroxymethylglutaryl-CoA Reductase Inhibitors

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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atorvastatin

atorvastatin 20mg tablet, single dose of 80mg by mouth

Group Type EXPERIMENTAL

atorvastatin

Intervention Type DRUG

placebo

placebo 20mg tablet, single dose of 80mg by mouth

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

Interventions

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atorvastatin

Intervention Type DRUG

placebo

Intervention Type DRUG

Other Intervention Names

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Liptor sugar pill manufactured to mimic atorvastatin 20mg tablet

Eligibility Criteria

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Inclusion Criteria

* healthy youth

Exclusion Criteria

* acute pathologies
* familial history of cardiovascular disease
* smoking or drinking alcohol
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Yi-jun Huang, PhD

Department of Pharmacology, Zhongshan School of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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YHuang002

Identifier Type: -

Identifier Source: org_study_id

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