Decompressive Cervical Surgery and Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-12-31

Brief Summary

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There is a relationship between CSM and hypertension, probably a cause/effect relationship, and investigators term this type of hypertension "cervicogenic hypertension". Abnormally functioning serotonergic pacemaker cells in the dorsal raphe nucleus inappropriately activate and inhibit parts of the central and autonomic nervous systems as part of a chronic stress response, which causes hypertension and migraine. This theory is now being expanded to encompass both CSM and essential hypertension, the idea being that these two conditions are intimately related.

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Detailed Description

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Cervical spondylotic myelopathy (CSM) and hypertension are both very common diseases in the general population.Investigators have also observed previously hypertensive patients with CSM become normotensive following decompressive cervical surgery and no longer need antihypertensive medications. Both observations are difficult to explain according to current theories of the two diseases.

Conditions

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Myelopathy, Compressive Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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operation

To make decompressive cervical surgery, either anterior cervical discectomy and fusion or posterior laminoplasty on the patients suffering from cervical spondylotic myelopathy and hypertension.

decompressive cervical surgery

Intervention Type PROCEDURE

To make decompressive cervical surgery, either anterior cervical discectomy and fusion or posterior laminoplasty on the patients suffering from cervical spondylotic myelopathy and hypertension.

Interventions

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decompressive cervical surgery

To make decompressive cervical surgery, either anterior cervical discectomy and fusion or posterior laminoplasty on the patients suffering from cervical spondylotic myelopathy and hypertension.

Intervention Type PROCEDURE

Other Intervention Names

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anterior cervical discectomy fusion posterior laminoplasty

Eligibility Criteria

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Inclusion Criteria

* Established diagnosis of cervical spondylosis myelopathy
* Be at least 18 years of age
* Office-measured systolic BP≧140mmHg
* Ability to adhere to study protocol
* Have signed an approved informed consent form for participation in this study

Exclusion Criteria

* Have hypertension secondary to a treatable cause
* Have prior cervical spine surgery
* Are pregnant or contemplating pregnancy during the 3-month follow-up period
* People deny to join the study
* Are unable to comply with protocol requirements
* Are unlikely to survive the protocol follow-up period
* Are enrolled in another concurrent clinical trial
* Visual Analogue Scale≥4

Minimum Eligible Age

18 Years

Maximum Eligible Age

84 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No