SUNBURST (Success Using Neuromodulation With BURST) Study

NCT ID: NCT02011893

Last Updated: 2019-01-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

173 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Study Completion Date

2017-01-31

Brief Summary

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The purpose of the study is to demonstrate the safety and efficacy of the Prodigy system for the treatment of chronic intractable pain of the trunk and/or limbs.

Detailed Description

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Conditions

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Chronic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Burst Stimulation

Burst Stimulation using the Prodigy system

Group Type EXPERIMENTAL

Burst Stimulation

Intervention Type DEVICE

Prodigy Neurostimulation System with associated components

Tonic Stimulation

Tonic Stimulation using the Prodigy system

Group Type ACTIVE_COMPARATOR

Tonic Stimulation

Intervention Type DEVICE

Prodigy Neurostimulation System with associated components

Interventions

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Tonic Stimulation

Prodigy Neurostimulation System with associated components

Intervention Type DEVICE

Burst Stimulation

Prodigy Neurostimulation System with associated components

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is 22 years of age or older
* Subject has chronic intractable pain of the trunk and/or limbs
* Subject has a average score of 60 or higher for average daily overall pain on the Visual Analog Scale (VAS) 7 day pain diary
* Subject has attempted "best" medical therapy and has tried and failed at least three documented medically supervised treatments (including, but not limited to physical therapy, acupuncture, etc.) and has failed medication treatment from at least two different classes
* Subject's pain-related medication regimen is stable 4 weeks prior to the baseline evaluation
* Subject agrees not to add or increase pain-related medication from activation through the 24 week follow-up visit

Exclusion Criteria

* Subject is currently participating in a clinical investigation that includes an active treatment arm
* Subject has been implanted with a previous neurostimulation system or participated in a trial period for a neurostimulation system
* Subject's overall Beck Depression Inventory II Score is \>24 or has a score of 3 on question 9 relating to suicidal thoughts or wishes at the screening visit
* Subject has an infusion pump or any implantable neurostimulator device
* Subjects with concurrent clinically significant or disabling chronic pain problem that requires additional treatment
* Subject has an existing medical condition that is likely to require repetitive Magnetic Resonance Imaging (MRI) evaluation in the future (i.e. epilepsy, stroke, multiple sclerosis, acoustic neuroma, tumor)
* Subject has an existing medical condition that is likely to require the use of diathermy in the future
* Subject's pain originates from peripheral vascular disease
* Subject is immunocompromised
* Subject has documented history of allergic response to titanium or silicone
* Subject has a documented history of substance abuse (narcotics, alcohol, etc.) or substance dependency in the 6 months prior to baseline data collection
* Female candidates of child bearing potential that are pregnant (confirmed by positive urine/blood pregnancy test)
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Timothy Deer, MD

Role: STUDY_CHAIR

The Center for Pain Relief

Locations

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Newport Beach Headache and Pain

Mission Viejo, California, United States

Site Status

Napa Biomedical Services

Napa, California, United States

Site Status

Eisenhower Desert Orthopedic Center

Rancho Mirage, California, United States

Site Status

IPM Medical Group

Walnut Creek, California, United States

Site Status

Goodman Campbell Brain and Spine

Indianapolis, Indiana, United States

Site Status

Bronson Neuroscience Center

Kalamazoo, Michigan, United States

Site Status

The Neuroscience Center

Biloxi, Mississippi, United States

Site Status

Jackson Pain Center

Jackson, Mississippi, United States

Site Status

Comprehensive Pain & Rehabilitation

Pascagoula, Mississippi, United States

Site Status

Midwest Neurosurgery Associates

Kansas City, Missouri, United States

Site Status

The Montana Center for Wellness & Pain Management

Kalispell, Montana, United States

Site Status

Albany Medical Center

Albany, New York, United States

Site Status

New York Spine & Wellness Center

North Syracuse, New York, United States

Site Status

Oklahoma Pain Physicians

Oklahoma City, Oklahoma, United States

Site Status

NeuroSpine Institute

Eugene, Oregon, United States

Site Status

St. Luke's Hospital

Bethlehem, Pennsylvania, United States

Site Status

Clinical Trials of South Carolina

North Charleston, South Carolina, United States

Site Status

Houston Pain Centers

Houston, Texas, United States

Site Status

Utah Spine Care

Ogden, Utah, United States

Site Status

The Center for Pain Relief

Charleston, West Virginia, United States

Site Status

Countries

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United States

References

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Slavin KV, North RB, Deer TR, Staats P, Davis K, Diaz R. Tonic and burst spinal cord stimulation waveforms for the treatment of chronic, intractable pain: study protocol for a randomized controlled trial. Trials. 2016 Dec 1;17(1):569. doi: 10.1186/s13063-016-1706-5.

Reference Type DERIVED
PMID: 27906080 (View on PubMed)

Other Identifiers

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C-12-07

Identifier Type: -

Identifier Source: org_study_id

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