Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women

NCT ID: NCT02005224

Last Updated: 2013-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-03-31

Brief Summary

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Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Detailed Description

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Conditions

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Insulin Sensitivity Weight

Keywords

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Insulin sensitivity Lipid profile Body composition Weight

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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LCHF diet and a bout of exercise

LCHF diet for 3 weeks, where E% 70 fat, E% 20-25 proteins and 20g or less carbohydrates. Oral glucose tolerance test on the morning of day 21 followed by a bout of exercise in the afternoon (indoor bicycle, 60min at 75% HFpeak). The following morning (day 22) a new oral glucose tolerance test. Oral glucose tolerance test results from pre-tests used to determine the effect of LCHF and a bout of exercise on insulin sensitivity.

Group Type OTHER

LCHF diet and a bout of exercise

Intervention Type OTHER

Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.

Interventions

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LCHF diet and a bout of exercise

Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Females
* Normal weight
* BMI between 18.5 and 25
* Moderately trained

Exclusion Criteria

* Smokers/tobacco users
* pregnancy
* familial cardio-vascular-disease
* diabetes or reduced glucose tolerance
* under- or overweight (BMI under 18.5 or over 25)
* top athletes
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Norwegian School of Sport Sciences

OTHER

Sponsor Role collaborator

Atlantis Medical University College

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jorgen Jensen, PhD

Role: STUDY_DIRECTOR

Norwegian School of Sport Sciences - Department of Physical Performance

Locations

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Norwegian School of Sport Sciences

Oslo, , Norway

Site Status

Countries

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Norway

Other Identifiers

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AMUC-NIH-LCHF-P1-2012

Identifier Type: -

Identifier Source: org_study_id