Post Approval Study of the TS Feature With the 530G Pump System Supplemented With Commercial Patient Data

NCT ID: NCT02003898

Last Updated: 2019-03-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

372 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-26

Study Completion Date

2018-02-20

Brief Summary

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The purpose of this study is to evaluate the Threshold Suspend (TS) feature of the Medtronic MiniMed® 530G insulin pump in patients 16 and older with insulin requiring diabetes.

Detailed Description

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Multi-center trial is initiated to observe the Threshold Suspend (TS) feature with a sensor-augmented insulin pump (Medtronic MiniMed® 530G insulin pump) in patients 16 and older with insulin requiring diabetes over a period of one year.

Conditions

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Diabetes

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All subjects are assigned to treatment with the Medtronic 530G Insulin Pump
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Medtronic MiniMed 530G Insulin Pump

All subjects received diabetes treatment using the Medtronic MiniMed 530G insulin pump.

Group Type EXPERIMENTAL

Medtronic MiniMed 530G Insulin Pump

Intervention Type DEVICE

Interventions

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Medtronic MiniMed 530G Insulin Pump

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subject is age 16 or older at time of screening
2. Subject has been diagnosed with diabetes mellitus for at least one year prior to screening.
3. Subject is currently on pump therapy.
4. Subject is transitioning to the 530G insulin pump system with the TS feature turned ON.
5. Subject is willing to complete all study related activities
6. Subject is willing to upload data every 21 days from the study pump
7. Subject must have Internet access and access to a computer system that meets the requirements for uploading the pumps. This may include use of family or friend's computer system with Internet access.
8. Subject is able (by insurance or financial means) to cover the initial investment and ongoing cost of the 530G insulin pump and consumables, CGM, Bayer CONTOUR Next Link RF enabled meter and supplies for the length of the study- 1 year.

Exclusion Criteria

1. Subject is actively participating in an investigational study (drug or device) wherein he/she has received treatment from an investigational study drug or investigational study devices in the last 2 weeks.
2. Subject is a woman of child-bearing potential who has a positive pregnancy test at screening or plans to become pregnant during the course of the study
3. Subject is being treated for hyperthyroidism at time of screening
4. Subject has an abnormality (\>1.8mg/dL) in creatinine at time of screening visit
5. Subject has an abnormality (out of reference range) in thyroid-stimulating hormone (TSH) at time of screening visit. If TSH is out of range, Free T3 and Free T4 will be tested. Subject may be included with TSH out of range as long as Free T3 and Free T4 are in normal reference range.
6. Subject has taken any oral, injectable, or IV steroids within 8 weeks from time of screening visit, or plans to take any oral, injectable, or IV steroids during the course of the study
7. Subject is currently abusing illicit drugs
8. Subject is currently abusing prescription drugs
9. Subject is currently abusing alcohol
10. Subject has sickle cell disease or hemoglobinopathy
11. Subject has received red blood cell transfusion or erythropoietin within 3 months prior to time of screening or plans to receive red blood cell transfusion or erythropoietin over the course of study participation
12. Subject diagnosed with current eating disorder such as anorexia or bulimia
13. Subject has been diagnosed with chronic kidney disease that results in chronic anemia
14. Subject is on dialysis
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Diabetes

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Scott Lee, MD

Role: STUDY_DIRECTOR

Medtronic Diabetes

Locations

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Medical Investigations, Inc.

Little Rock, Arkansas, United States

Site Status

AMCR Institute

Escondido, California, United States

Site Status

Valley Research

Fresno, California, United States

Site Status

Center of Excellence in Diabetes & Endocrinology

Sacramento, California, United States

Site Status

So Cal Diabetes

Torrance, California, United States

Site Status

Barbara Davis Center (1)

Aurora, Colorado, United States

Site Status

Barbara Davis Center (2)

Aurora, Colorado, United States

Site Status

East Coast Institute for Research

Jacksonville, Florida, United States

Site Status

Endocrine Associates of Florida, P.A.

Lake Mary, Florida, United States

Site Status

TLC Diabetes Healthcare Consultants & Education Inc.

Naples, Florida, United States

Site Status

Pediatric Endocrine Associates

Tampa, Florida, United States

Site Status

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Site Status

East Alabama Endocrinology PC

Columbus, Georgia, United States

Site Status

Endocrine Research Solutions

Roswell, Georgia, United States

Site Status

The University of Chicago

Chicago, Illinois, United States

Site Status

Isaiah Pittman IV, MD

Terre Haute, Indiana, United States

Site Status

Good Samaritan Hospital Physician Services

Vincennes, Indiana, United States

Site Status

Iowa Diabetes and Endocrinology Center

Des Moines, Iowa, United States

Site Status

Imperial Health

Lake Charles, Louisiana, United States

Site Status

Eastern Shore Diabetes and Endocrinology Center

Salisbury, Maryland, United States

Site Status

University of Michigan Diabetes Research Center

Ann Arbor, Michigan, United States

Site Status

Grunberger Diabetes Institute

Bloomfield Hills, Michigan, United States

Site Status

Spectrum Health System

Grand Rapids, Michigan, United States

Site Status

International Diabetes Center

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

The Diabetes Center

Ocean Springs, Mississippi, United States

Site Status

The Children's Mercy Hospital

Kansas City, Missouri, United States

Site Status

Billings Clinic

Billings, Montana, United States

Site Status

Glacier View Research Institute-Endocrinology

Kalispell, Montana, United States

Site Status

Complete Endocrinology

Lincoln, Nebraska, United States

Site Status

Diabetes, Endocrinology, Metabolism Specialties

Teaneck, New Jersey, United States

Site Status

Winthrop University Hospital

Mineola, New York, United States

Site Status

Rochester General Hospital

Rochester, New York, United States

Site Status

Joslin Diabetes Center

Syracuse, New York, United States

Site Status

University at Buffalo, The State University of New York

Williamsville, New York, United States

Site Status

Physicians East, PA

Greenville, North Carolina, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

AM Diabetes and Endocrinology Center

Bartlett, Tennessee, United States

Site Status

Endeavor Clinical Trials

San Antonio, Texas, United States

Site Status

Consano Clinical Research, LLC

San Antonio, Texas, United States

Site Status

Northeast Clinical Research of San Antonio, LLC

Schertz, Texas, United States

Site Status

Southwestern Vermont Health Care

Bennington, Vermont, United States

Site Status

Tri-Cities Diabetes and Endocrinology Center

Richland, Washington, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CEP266

Identifier Type: -

Identifier Source: org_study_id

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