Trial Outcomes & Findings for Jugular Venous Flow Healthy Volunteers (NCT NCT02002494)

Results Overview

Comparisons of both jugular vein (IJV) of twenty-seven volunteers in supine and prone positions.

Recruitment status

COMPLETED

Target enrollment

27 participants

Primary outcome timeframe

1 day

Results posted on

2020-06-04

Participant Flow

Twenty-seven volunteers were included in this study.

Participant milestones

Participant milestones
Measure	Volunteers in Different Positions The following will be compared in the same volunteer: * Bilateral internal jugular venous flow in supine and prone position * Bilateral internal jugular venous flow in supine and park bench position * Bilateral internal jugular venous flow in prone and park bench Different positions: Jugular venous blood flow in healthy volunteers in 3 different positions- supine, prone and park bench
Overall Study STARTED	27
Overall Study COMPLETED	27
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Jugular Venous Flow Healthy Volunteers

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Volunteers in Different Positions n=27 Participants The following will be compared in the same volunteer: * Bilateral internal jugular venous flow in supine and prone position * Bilateral internal jugular venous flow in supine and park bench position * Bilateral internal jugular venous flow in prone and park bench Different positions: Jugular venous blood flow in healthy volunteers in 3 different positions- supine, prone and park bench
Age, Customized	38 years STANDARD_DEVIATION 10 • n=5 Participants
Sex/Gender, Customized	27 participants n=5 Participants
Height	169.5 units on a scale STANDARD_DEVIATION 12.5 • n=5 Participants
Weight	71.8 units on a scale STANDARD_DEVIATION 15.4 • n=5 Participants

PRIMARY outcome

Timeframe: 1 day

Population: Twenty-seven volunteers were included in this study. Comparisons of right and left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.

Comparisons of both jugular vein (IJV) of twenty-seven volunteers in supine and prone positions.

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
Internal Jugular Venous (IJV) Cross Sectional Area Supine-Cross sectional area	1.2 cm2 Standard Deviation 0.6	1.0 cm2 Standard Deviation 0.3
Internal Jugular Venous (IJV) Cross Sectional Area Prone-Cross sectional area	1.8 cm2 Standard Deviation 1	1.4 cm2 Standard Deviation 0.4

PRIMARY outcome

Timeframe: 1 day

Population: Comparisons of bilateral internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and right park bench position.

Twenty-seven volunteers were included in this study. Comparisons of cross sectional area measurements in both IJVs between supine and right park bench

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
Right and Left IJV Cross Sectional Area Supine-Cross sectional area (cm2)	1.2 cm2 Standard Deviation 0.6	1.0 cm2 Standard Deviation 0.3
Right and Left IJV Cross Sectional Area Right park bench-Cross sectional area	0.9 cm2 Standard Deviation 0.5	1.1 cm2 Standard Deviation 0.5

PRIMARY outcome

Timeframe: 1 day

Population: Comparisons of bilateral internal jugular vein (IJV) Doppler velocity between supine and prone position. Data presented as mean (SD) .

27 volunteers enrolled to measure the Internal Jugular Venous (IJV) in supine and prone positions

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
Internal Jugular Venous (IJV) Doppler Velocity Supine Doppler velocity	19.9 cm.sec-1 Standard Deviation 7	18.1 cm.sec-1 Standard Deviation 8.4
Internal Jugular Venous (IJV) Doppler Velocity Prone Doppler velocity	19.3 cm.sec-1 Standard Deviation 7.9	13.6 cm.sec-1 Standard Deviation 7.7

PRIMARY outcome

Timeframe: 1 day

Population: Comparisons of bilateral internal jugular vein (IJV) flow between supine and prone position. Data presented as mean (SD) .

Comparisons of bilateral internal jugular vein (IJV) flow between supine and prone position. Data presented as mean (SD) .

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
Bilateral Internal Jugular Vein (IJV) Flow Supine Flow	1430.1 ml.min-1 Standard Deviation 803	1112.9 ml.min-1 Standard Deviation 578.1
Bilateral Internal Jugular Vein (IJV) Flow Prone Flow	1924.2 ml.min-1 Standard Deviation 1139.7	1178.4 ml.min-1 Standard Deviation 832.1

PRIMARY outcome

Timeframe: 1 day

Population: Comparisons of bilateral internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and right park bench position. Data presented as mean (SD).

Comparisons of bilateral internal jugular vein (IJV) Doppler velocity between supine and right park bench position.

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
Bilateral Internal Jugular Vein (IJV) Doppler Velocity supine Doppler velocity	19.9 cm.sec-1 Standard Deviation 7	18.1 cm.sec-1 Standard Deviation 8.4
Bilateral Internal Jugular Vein (IJV) Doppler Velocity right park bench Doppler velocity	28.1 cm.sec-1 Standard Deviation 12	18.7 cm.sec-1 Standard Deviation 11.6

PRIMARY outcome

Timeframe: 1 day

Population: Comparisons of bilateral internal jugular vein (IJV) flow between supine and right park bench position. Data presented as mean (SD).

Bilateral internal jugular vein (IJV) flow between supine and right park bench position.

Outcome measures

Outcome measures
Measure	R IJV n=27 Participants Comparisons of right internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.	L IJV n=27 Participants Comparisons of left internal jugular vein (IJV) cross sectional area, Doppler velocity and flow between supine and prone position.
R IJV and L IJV Flow supine Flow	1430.1 ml.min-1 Standard Deviation 803	1112.9 ml.min-1 Standard Deviation 578.1
R IJV and L IJV Flow right park bench Flow	1403.1 ml.min-1 Standard Deviation 1006.1	1266.9 ml.min-1 Standard Deviation 959.6

Adverse Events

Volunteers in Different Positions

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Emad Al Azazi

Toronto Western Hospital/UHN

Phone: 416-603-8500

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place