Evaluation of the Effects of an Exogenous Phytase on Iron Absorption From LNS Added to Complementary Foods
NCT ID: NCT01991626
Last Updated: 2015-09-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
47 participants
INTERVENTIONAL
2013-09-30
2014-08-31
Brief Summary
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Furthermore the investigators will evaluate the effects of Lipids- on iron absorption to induce the ileal brake by ingestion of a fat emulsion prior to a meal. Increasing the caloric density of a meal by increasing its fat content might enhance iron absorption by delaying gastric emptying, gastric acid secretion and increasing Fe stomach residence time.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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LNS
Maize meal mixed with Lipid Nutrient Supplement (LNS) containing micronutrient powder
micronutrient powder
FePP-Emulsion mixed
Fat emulsion mixed to the meal containing FePP
Iron pyrophosphate (FePP)
FeSO4-Mixed
meals containing FeSO4 mixed with a fat emulsion
Iron sulphate
FePP-Emulsion before
Fat emulsion taken before a meal containing FePP
Iron pyrophosphate (FePP)
FeSO4- Emulsion before
Fat emulsion taken before a maize meal containing FeSO4
Iron sulphate
LNS-Phytase
Maize meal mixed with LNS containing micronutrient powder and phytase
micronutrient powder (containing FeSO4), phytase
phytase
Maize meal containing micronutrient powder and phytase
micronutrient powder (containing FeSO4), phytase
MNP-control
maize meal containing micronutrient powder (MNP)
micronutrient powder
FePP control
Maize meal containing FePP
Iron pyrophosphate (FePP)
FeSO4 control
Maize meal containing FeSO4
Iron sulphate
Interventions
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micronutrient powder
micronutrient powder (containing FeSO4), phytase
Iron pyrophosphate (FePP)
Iron sulphate
Eligibility Criteria
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Inclusion Criteria
* Normal body mass index (17.5-25 kg/m2)
* No intake of mineral/vitamin supplements 2 weeks before and during the study
* No metabolic or gastrointestinal disorders
* No food allergies or other chronic disorders or eating disorders assessed by self-report
* Having received full oral and written information about the aims and procedures of the study
* Willing to comply with the study procedure
* Having provided oral and written informed consent
Exclusion Criteria
* Blood donation or significant blood loss (accident, surgery) over the past 4 months
* Currently participating in another clinical trial or having participated in another clinical trial during the last 30 days prior to the beginning of this study
* Former participation in a study involving administration of iron stable isotopes
* Subject who cannot be expected to comply with study protocol
* Pregnancy or lactation
18 Years
45 Years
FEMALE
Yes
Sponsors
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DSM Nutritional Products, Inc.
INDUSTRY
Swiss Federal Institute of Technology
OTHER
Responsible Party
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Prof. Michael B. Zimmermann
Prof
Principal Investigators
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Michael B Zimmermann, Prof
Role: PRINCIPAL_INVESTIGATOR
ETH Zürich
References
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Monnard A, Moretti D, Zeder C, Steingotter A, Zimmermann MB. The effect of lipids, a lipid-rich ready-to-use therapeutic food, or a phytase on iron absorption from maize-based meals fortified with micronutrient powders. Am J Clin Nutr. 2017 Jun;105(6):1521-1527. doi: 10.3945/ajcn.116.142976. Epub 2017 May 3.
Other Identifiers
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Fe-LNS
Identifier Type: -
Identifier Source: org_study_id
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