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Iron Absorption From Biofortified Beans With Different Levels of Phytic Acid

NCT ID: NCT01521273

Last Updated: 2012-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2012-09-30

Brief Summary

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Iron deficiency and iron deficiency anemia are among the major health problems in the developing world. Women of childbearing age as well as children are the most vulnerable population groups. In Rwanda, more than 40% of the population is estimated to be anemic. A promising approach to combat iron deficiency in Rwanda is biofortification of beans. The average consumption of beans is about 150 g per person per day in Rwanda and beans are a major staple food. Traditional plant breeding has increased the iron content of certain bean varieties from about 5 to 11 mg/100g. Iron absorption from beans however is with about 2-3% low because of high phytate and high polyphenol contents. A recently conducted study in Rwanda showed that the total amount of iron absorbed from a biofortified high iron bean was similar to the amount of iron absorbed from a control bean, which had a 50% lower iron concentration. This was surprising since the subjects had a low iron status and where therefore expected to maximize iron absorption. However, it was concluded that the additional iron bred into the bean was not bioavailable most likely due to the strong inhibitory nature of phytate in the high iron bean. To clarify that, a multiple meal study (iron absorption study) in collaboration of the Human Nutrition Laboratory of ETH Zurich and the Medical Faculty of the National University of Rwanda is planned. Subjects will receive two different bean varieties (normal iron vs. high iron) in combination with other food ingredients typical for that region. The bean varieties will be served with native phytate concentration, partially dephytinized (50%) or totally dephytinized.

Subjects will be apparently healthy females of reproductive age (18-30y). Iron absorption will be determined by stable isotope techniques.

Detailed Description

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Conditions

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Enrichment of Blood

Keywords

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beans biofortification phytic acid iron iron isotopes different phytic acid concentrations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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high iron bean with native phytic acid concentration

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

normal iron bean with native phytic acid concentration

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

high iron bean partially dephytinized

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

normal iron bean partially dephytinized

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

high iron bean totally dephytinized

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

normal iron bean totally dephytinized

Group Type EXPERIMENTAL

Bean varieties

Intervention Type OTHER

10 x 50 g/ arm

Interventions

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Bean varieties

10 x 50 g/ arm

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Non-pregnant, non-lactating women
* Between 18 and 40 years
* Below 65kg

Exclusion Criteria

* Metabolic, chronic and gastro-intestinal disease
* Long-term medication
* Blood donation within 6 month before the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Swiss Federal Institute of Technology

OTHER

Sponsor Role lead

Responsible Party

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Prof. Michael B. Zimmermann

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Richard Hurrell, Prof. Dr.

Role: STUDY_DIRECTOR

Swiss Federal Institute of Technology

Locations

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National University of Rwanda (NUR)

Butare, , Rwanda

Site Status

Countries

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Rwanda

References

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Petry N, Egli I, Gahutu JB, Tugirimana PL, Boy E, Hurrell R. Phytic acid concentration influences iron bioavailability from biofortified beans in Rwandese women with low iron status. J Nutr. 2014 Nov;144(11):1681-7. doi: 10.3945/jn.114.192989. Epub 2014 Sep 3.

Reference Type DERIVED
PMID: 25332466 (View on PubMed)

Other Identifiers

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Rwa3

Identifier Type: -

Identifier Source: org_study_id