Comparison of Two Formulations of Androxal

NCT ID: NCT01984398

Last Updated: 2019-05-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Study Completion Date

2013-12-31

Brief Summary

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To determine and compare the pharmacokinetics (PK) of a single dose of each of two formulations Androxal

Detailed Description

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To determine and compare the pharmacokinetics (PK) of a single dose of each of two formulations of 12.5 mg and 25 mg Androxal administered to healthy male volunteers, and to determine and compare the safety of a single dose each of two formulations of 12.5 mg and 25 mg Androxal administered to healthy male volunteers.

Conditions

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Bioequivalence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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12.5 mg Androxal (formulations A and B)

12.5 mg Androxal formulation A and 12.5 mg Androxal formulation B, a single dose of each formulation

Group Type EXPERIMENTAL

12.5 mg Androxal Formulation A

Intervention Type DRUG

Single dose of 12.5 mg Androxal formulation A

12.5 mg Androxal Formulation B

Intervention Type DRUG

Single dose of 12.5 mg Androxal Formulation B

25 mg Androxal (formulations A and B)

25 mg Androxal formulation A and 12.5 mg Androxal formulation B, a single dose of each formulation

Group Type EXPERIMENTAL

25 mg Androxal Formulation A

Intervention Type DRUG

Single dose of 25 mg Androxal formulation A

25 mg Androxal Formulation B

Intervention Type DRUG

Single dose of 25 mg Androxal formulation B

Interventions

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12.5 mg Androxal Formulation A

Single dose of 12.5 mg Androxal formulation A

Intervention Type DRUG

12.5 mg Androxal Formulation B

Single dose of 12.5 mg Androxal Formulation B

Intervention Type DRUG

25 mg Androxal Formulation A

Single dose of 25 mg Androxal formulation A

Intervention Type DRUG

25 mg Androxal Formulation B

Single dose of 25 mg Androxal formulation B

Intervention Type DRUG

Other Intervention Names

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enclomiphene citrate enclomiphene citrate enclomiphene citrate enclomiphene citrate

Eligibility Criteria

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Inclusion Criteria

* Speaks, reads, and understands English or Spanish and is willing and able to provide written informed consent on an Institutional Review Board (IRB)-approved form prior to the initiation of any study procedures;
* Male, between the ages of 18-60 years;
* No significant abnormal findings at the screening physical examination as evaluated by the Investigator;
* Normal laboratory values (or abnormal but not clinically significant) at screening as determined by the Investigator;
* Subject is willing to remain in the clinic overnight for the Day 1 and Day 6 visits;
* Must be able to swallow gelatin capsules

Exclusion Criteria

* Known hypersensitivity to Clomid;
* Abnormal screening visit vital signs or clinical laboratory evaluation considered clinically significant by the Investigator;
* Subject with a significant organ abnormality or disease as determined by the Investigator;
* Any medical condition that would interfere with the study as determined by the Investigator;
* Slow Cytochrome P4502D6 (CYP2D6) metabolizer
* Participation in a clinical trial with investigational medication within 30 days prior to study medication administration;
* An acute illness within 5 days of study medication administration;;
* A mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study and/or evidence of an uncooperative attitude, as determined by the Investigator;
* History of venous thromboembolic disease (e.g. deep vein thrombosis or pulmonary embolism);
* History of myocardial infarction, unstable angina, symptomatic heart failure, ventricular dysrhythmia, or known history of (corrected QT) QTc interval prolongation;
* An employee or family member of an employee of the study site or the Sponsor.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Repros Therapeutics Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anna Chan

Role: STUDY_DIRECTOR

Allergan

Locations

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Clinical Pharmacology of miami

Miami, Florida, United States

Site Status

Countries

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United States

Related Links

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http://www.reprosrx.com

Sponsor Corporate Website

Other Identifiers

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ZA-110

Identifier Type: -

Identifier Source: org_study_id

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