Thorough QT Study to Evaluate the Effects of BI 207127 (Deleobuvir) Combined With Faldaprevir on Cardiac Safety Parameters in Healthy Subjects.

NCT ID: NCT01965431

Last Updated: 2016-04-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-01-31

Brief Summary

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The objective of this study is to evaluate the effect of multiple doses of BI 207127 combined with faldaprevir on cardiac safety parameters in healthy subjects

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Study Groups

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BI 207127 + Faldaprevir

Tablets/capsules

Group Type EXPERIMENTAL

BI 207127

Intervention Type DRUG

Medium dose oral administration

Faldaprevir

Intervention Type DRUG

Medium dose oral administration

Moxifloxacin (Avalox®)

Tablets

Group Type ACTIVE_COMPARATOR

Moxifloxacin (Avalox®)

Intervention Type DRUG

BI 207127 placebo + Faldaprevir placebo

Tablets/capsules

Group Type EXPERIMENTAL

BI 207127 placebo

Intervention Type DRUG

Faldaprevir placebo

Intervention Type DRUG

Interventions

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BI 207127

Medium dose oral administration

Intervention Type DRUG

BI 207127 placebo

Intervention Type DRUG

Faldaprevir placebo

Intervention Type DRUG

Faldaprevir

Medium dose oral administration

Intervention Type DRUG

Moxifloxacin (Avalox®)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy male and female subjects
* Subjects must be able to understand and comply with study requirements
* Age =18 and =55 years
* BMI range: =18.5 and =29.9 kg/m2

Exclusion Criteria

\- any relevant deviation from healthy conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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1241.40.1 Boehringer Ingelheim Investigational Site

Ingelheim, , Germany

Site Status

Countries

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Germany

Other Identifiers

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2013-002741-11

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1241.40

Identifier Type: -

Identifier Source: org_study_id

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