Open-label Study of Dupilumab in Patients With Atopic Dermatitis
NCT ID: NCT01949311
Last Updated: 2023-10-17
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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COMPLETED
PHASE3
2733 participants
INTERVENTIONAL
2013-10-10
2022-06-27
Brief Summary
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The secondary objective of the study is to assess the immunogenicity of dupilumab in adult participants with AD, in the context of re-treatment, and to monitor efficacy parameters associated with long-term treatment.
Optional Sub-Study:
The primary objective of the sub-study is to assess the safety of the new dupilumab drug product in adult patients with AD after switching from the current dupilumab drug product.
The secondary objectives of the sub-study are to evaluate systemic exposure and immunogenicity of the new dupilumab drug product in adult patients with AD.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Dupilumab
Participants will receive repeat doses of dupilumab
Dupilumab
Interventions
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Dupilumab
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
1. Received study treatment and adequately completed the assessments required for both the treatment and follow-up periods of the parent studies (except studies listed in b) as defined in the parent protocols
2. Received study treatment in one the studies that have completed last patient, last visit irrespective of duration of participation, provided that patients completed with the instructions received during the study.
3. Underwent screening in R668-AD-1334 (Liberty AD SOLO 1) or R668-AD-1416 (Liberty AD SOLO 2) but could not be randomized due to randomization closure.
2. Willing and able to comply with all clinic visits and study-related procedures
3. Able to understand and complete study-related questionnaires
4. Provide signed informed consent
Optional Sub-Study:
1. Provide separate informed consent
2. Continuing in the treatment period of the main OLE study
3. Demonstrated compliance with dupilumab therapy, as defined in the protocol
Exclusion Criteria
2. Patients who, during their participation in a previous dupilumab clinical trial, developed an AE that was deemed related to dupilumab\* and led to study treatment discontinuation, which in the opinion of the investigator or of the medical monitor could indicate that continued treatment with dupilumab may present an unreasonable risk for the patient.
3. Conditions in the previous dupilumab study consistent with protocol-defined criteria for permanent study drug discontinuation, if deemed related to dupilumab\* or led to investigator - or sponsor-initiated withdrawal of patient from the study (eg, non-compliance, inability to complete study assessments, etc.).
4. Treatment with an investigational drug, other than dupilumab, within 8 weeks or within 5 half-lives (if known), whichever is longer, before the baseline visit
5. Pregnant or breastfeeding women, or planning to become pregnant or breastfeed during the patient's participation in this study
Optional Sub-Study:
1\. Patients who have already completed the end of treatment visit (ie, visit 44) for the main study R668-AD-1225
18 Years
ALL
No
Sponsors
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Sanofi
INDUSTRY
Regeneron Pharmaceuticals
INDUSTRY
Responsible Party
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Principal Investigators
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Clinical Trial Management
Role: STUDY_DIRECTOR
Regeneron Pharmaceuticals
Locations
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Regeneron Study Site
Anniston, Alabama, United States
Regeneron Study Site
Birmingham, Alabama, United States
Regeneron Study Site 1
Birmingham, Alabama, United States
Regeneron Study Site 2
Birmingham, Alabama, United States
Regeneron Study Site 2
Phoenix, Arizona, United States
Regeneron Study Site 3
Phoenix, Arizona, United States
Regeneron Study Site 1
Phoenix, Arizona, United States
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Fort Smith, Arkansas, United States
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Rogers, Arkansas, United States
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Bakersfield, California, United States
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Clovis, California, United States
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Costa Mesa, California, United States
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Encinitas, California, United States
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Fremont, California, United States
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Lomita, California, United States
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Long Beach, California, United States
Regeneron Study Site 1
Los Angeles, California, United States
Regeneron Study Site 2
Los Angeles, California, United States
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Los Angeles, California, United States
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Oceanside, California, United States
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Orange, California, United States
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Rolling Hills Estates, California, United States
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San Diego, California, United States
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San Diego, California, United States
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San Diego, California, United States
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Santa Monica, California, United States
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Centennial, Colorado, United States
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Denver, Colorado, United States
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Denver, Colorado, United States
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Trumbull, Connecticut, United States
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Washington D.C., District of Columbia, United States
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Boca Raton, Florida, United States
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Clearwater, Florida, United States
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Fort Lauderdale, Florida, United States
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Jacksonville, Florida, United States
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Jacksonville, Florida, United States
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Lake Worth, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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Orlando, Florida, United States
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Tampa, Florida, United States
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Tampa, Florida, United States
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Tampa, Florida, United States
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West Palm Beach, Florida, United States
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Alpharetta, Georgia, United States
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Atlanta, Georgia, United States
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Columbus, Georgia, United States
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Macon, Georgia, United States
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Newnan, Georgia, United States
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Sandy Springs, Georgia, United States
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Savannah, Georgia, United States
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Chicago, Illinois, United States
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Normal, Illinois, United States
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West Dundee, Illinois, United States
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Indianapolis, Indiana, United States
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Newburgh, Indiana, United States
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Plainfield, Indiana, United States
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Overland Park, Kansas, United States
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New Orleans, Louisiana, United States
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Rockville, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Bay City, Michigan, United States
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Farmington Hills, Michigan, United States
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Troy, Michigan, United States
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Edina, Minnesota, United States
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Fridley, Minnesota, United States
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Minneapolis, Minnesota, United States
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Plymouth, Minnesota, United States
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Saint Joseph, Missouri, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Henderson, Nevada, United States
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Las Vegas, Nevada, United States
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Portsmouth, New Hampshire, United States
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Berlin, New Jersey, United States
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East Windsor, New Jersey, United States
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Verona, New Jersey, United States
Regeneron Study Site 1
Albuquerque, New Mexico, United States
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Albuquerque, New Mexico, United States
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Buffalo, New York, United States
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Corning, New York, United States
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Forest Hills, New York, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Rochester, New York, United States
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Chapel Hill, North Carolina, United States
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High Point, North Carolina, United States
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Raleigh, North Carolina, United States
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Wilmington, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Cincinnati, Ohio, United States
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Cleveland, Ohio, United States
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Norman, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Medford, Oregon, United States
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Portland, Oregon, United States
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Portland, Oregon, United States
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Bethlehem, Pennsylvania, United States
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Jenkintown, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Charleston, South Carolina, United States
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Greer, South Carolina, United States
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Chattanooga, Tennessee, United States
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Nashville, Tennessee, United States
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Arlington, Texas, United States
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Austin, Texas, United States
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Bellaire, Texas, United States
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Dallas, Texas, United States
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Dallas, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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Waco, Texas, United States
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Webster, Texas, United States
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Salt Lake City, Utah, United States
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South Burlington, Vermont, United States
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Newport News, Virginia, United States
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Norfolk, Virginia, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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Phillip, Australian Capital Territory, Australia
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Kogarah, New South Wales, Australia
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Benowa, Queensland, Australia
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Woolloongabba, Queensland, Australia
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Hectorville, South Australia, Australia
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Carlton, Victoria, Australia
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East Melbourne, Victoria, Australia
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Fremantle, Western Australia, Australia
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Vienna, , Austria
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Vienna, , Austria
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Brussels, Brussels Capital, Belgium
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Loverval, Hainaut, Belgium
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Leuven, Vlaams Brabant, Belgium
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Dupnitsa, Kyustendil, Bulgaria
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Sofia, Sofia-Grad, Bulgaria
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Sofia, Sofia-Grad, Bulgaria
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Calgary, Alberta, Canada
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Edmonton, Alberta, Canada
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Surrey, British Columbia, Canada
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Surrey, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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Bathurst, New Brunswick, Canada
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St. John's, Newfoundland and Labrador, Canada
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Ajax, Ontario, Canada
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Barrie, Ontario, Canada
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Barrie, Ontario, Canada
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Etobicoke, Ontario, Canada
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Hamilton, Ontario, Canada
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Hamilton, Ontario, Canada
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Markham, Ontario, Canada
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Mississauga, Ontario, Canada
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Newmarket, Ontario, Canada
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North Bay, Ontario, Canada
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Oakville, Ontario, Canada
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Ottawa, Ontario, Canada
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Peterborough, Ontario, Canada
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Richmond Hill, Ontario, Canada
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Richmond Hill, Ontario, Canada
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Toronto, Ontario, Canada
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Waterloo, Ontario, Canada
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Windsor, Ontario, Canada
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Windsor, Ontario, Canada
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Drummondville, Quebec, Canada
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Montreal, Quebec, Canada
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Ste-Foy, Quebec, Canada
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Ste-Foy, , Canada
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Winnipeg, , Canada
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Hong Kong, , China
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Hradec Králové, , Czechia
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Kutná Hora, , Czechia
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Náchod, , Czechia
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Prague, , Czechia
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Svitavy, , Czechia
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Ústí nad Labem, , Czechia
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Copenhagen, Capital, Denmark
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Hellerup, Capital, Denmark
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Aarhus, Central Jutland, Denmark
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Roskilde, Zeeland, Denmark
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Tallinn, Harju, Estonia
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Tallinn, Harju, Estonia
Regeneron Study Site 3
Tallinn, Harju, Estonia
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Tartu, Tartu, Estonia
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Tartu, Tartu, Estonia
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Helsinki, Etelä-Suomen Iääni, Finland
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Turku, Etelä-Suomen Lääni, Finland
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Tampere, Länsi-Suomen Lääni, Finland
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Nice, Alpes-Maritimes, France
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Pierre-Bénite, Auvergne-Rhône-Alpes, France
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Marseille, Bouches-du-Rhône, France
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Reims, Marne, France
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Lille, Nord, France
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Lille, , France
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Nantes, , France
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Paris, Île-de-France Region, France
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Friedrichshafen, Baden-Wurttemberg, Germany
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Heidelberg, Baden-Wurttemberg, Germany
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Langenau, Baden-Wurttemberg, Germany
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Stuttgart, Baden-Wurttemberg, Germany
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Tübingen, Baden-Wurttemberg, Germany
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Augsburg, Bavaria, Germany
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Erlangen, Bavaria, Germany
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Munich, Bavaria, Germany
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München, Bavaria, Germany
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Mahlow, Brandenburg, Germany
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Hamburg, City state of Hamburg, Germany
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Frankfurt am Main, Hesse, Germany
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Hanover, Lower Saxony, Germany
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Schwerin, Mecklenburg-Vorpommern, Germany
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Bochum, North Rhine-Westphalia, Germany
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Bochum, North Rhine-Westphalia, Germany
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Dülmen, North Rhine-Westphalia, Germany
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Ibbenbueren, North Rhine-Westphalia, Germany
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Mönchengladbach, North Rhine-Westphalia, Germany
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Münster, North Rhine-Westphalia, Germany
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Mainz, Rhineland-Palatinate, Germany
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Selters, Rhineland-Palatinate, Germany
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Dresden, Saxony, Germany
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Dresden, Saxony, Germany
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Dresden, Saxony, Germany
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Leipzig, Saxony, Germany
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Halle, Saxony-Anhalt, Germany
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Magdeburg, Saxony-Anhalt, Germany
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Kiel, Schleswig-Holstein, Germany
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Kiel, Schleswig-Holstein, Germany
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Lübeck, Schleswig-Holstein, Germany
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Gera, Thuringia, Germany
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Berlin, , Germany
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Berlin, , Germany
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Berlin, , Germany
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Berlin, , Germany
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Berlin, , Germany
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Berlin, , Germany
Regeneron Study Site 7
Berlin, , Germany
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Bonn, , Germany
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Darmstadt, , Germany
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Hamburg, , Germany
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Münster, , Germany
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Osnabrück, , Germany
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Orosháza, Bekes County, Hungary
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Sátoraljaújhely, Borsod-Abauj Zemplen county, Hungary
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Szeged, Csongrád megye, Hungary
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Szolnok, Jász-Nagykun-Szolnok, Hungary
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Kaposvár, Somogy County, Hungary
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Budapest, , Hungary
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Budapest, , Hungary
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Budapest, , Hungary
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Veszprém, , Hungary
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Dublin, , Ireland
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Bologna, Balogna, Italy
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Ancona, , Italy
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Chieti, , Italy
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Florence, , Italy
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Lucca, , Italy
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L’Aquila, , Italy
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Messina, , Italy
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Milan, , Italy
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Novara, , Italy
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Pavia, , Italy
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Perugia, , Italy
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Pisa, , Italy
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Roma, , Italy
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Roma, , Italy
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Nagakute, Aichi-ken, Japan
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Kurume, Fukuoka, Japan
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Fukuyama, Hiroshima, Japan
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Sapporo, Hokkaido, Japan
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Fukuoka, Hukuoka, Japan
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Fukuoka, Hukuoka, Japan
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Kitakyushu, Hukuoka, Japan
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Amagasaki, Hyôgo, Japan
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Amagasaki, Hyôgo, Japan
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Inashiki-gun, Ibaraki, Japan
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Yokohama, Kanagawa, Japan
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Yokohama, Kanagawa, Japan
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Yokohama, Kanagawa, Japan
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Kamimashiki, Kumamoto, Japan
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Habikino, Osaka, Japan
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Neyagawa, Osaka, Japan
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Sakai, Osaka, Japan
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Takatsuki, Osaka, Japan
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Hamamatsu, Shizuoka, Japan
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Yaizu, Shizuoka, Japan
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Bunkyo-ku, Tokyo, Japan
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Bunkyo-ku, Tokyo, Japan
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Chiyoda-ku, Tokyo, Japan
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Chiyoda-ku, Tokyo, Japan
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Chuo-ku, Tokyo, Japan
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Koto-ku, Tokyo, Japan
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Nakano-ku, Tokyo, Japan
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Nerima City, Tokyo, Japan
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Nerima City, Tokyo, Japan
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Ōta-ku, Tokyo, Japan
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Setagaya-ku, Tokyo, Japan
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Shibuya-ku, Tokyo, Japan
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Shibuya-ku, Tokyo, Japan
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Shibuya-ku, Tokyo, Japan
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Shinagawa-ku, Tokyo, Japan
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Shinagawa-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Shinjuku-ku, Tokyo, Japan
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Suginami, Tokyo, Japan
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Suginami, Tokyo, Japan
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Chūō, Yamanashi, Japan
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Kofu, Yamanashi, Japan
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Fukuyama, , Japan
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Gifu, , Japan
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Hiroshima, , Japan
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Hiroshima, , Japan
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Kyoto, , Japan
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Kyoto, , Japan
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Osaka, , Japan
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Osaka, , Japan
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Saitama, , Japan
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Shinagawa-ku, , Japan
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Suginome, , Japan
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Wakayama, , Japan
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Yokohama, , Japan
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Kaunas, Kaunas County, Lithuania
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Vilnius, Vilnius County, Lithuania
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Vilnius, Vilnius County, Lithuania
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Klaipėda, , Lithuania
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Klaipėda, , Lithuania
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Breda, North Brabant, Netherlands
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Amsterdam, North Holland, Netherlands
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Rotterdam, South Holland, Netherlands
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Groningen, , Netherlands
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Utrecht, , Netherlands
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Dunedin, South Island, New Zealand
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Auckland, , New Zealand
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Poznan, Greater Poland Voivodeship, Poland
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Poznan, Greater Poland Voivodeship, Poland
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Poznan, Greater Poland Voivodeship, Poland
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Torun, Kuyavian-Pomeranian Voivodeship, Poland
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Krakow, Lesser Poland Voivodeship, Poland
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Krakow, Lesser Poland Voivodeship, Poland
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Krakow, Lesser Poland Voivodeship, Poland
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Wroclaw, Lower Silesian Voivodeship, Poland
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Wroclaw, Lower Silesian Voivodeship, Poland
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Wroclaw, Lower Silesian Voivodeship, Poland
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Lublin, Lublin Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Warsaw, Masovian Voivodeship, Poland
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Strzelce Opolskie, Opole Voivodeship, Poland
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Iwonicz-Zdrój, Podkarpackie Voivodeship, Poland
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Gdansk, Pomeranian Voivodeship, Poland
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Gdansk, Pomeranian Voivodeship, Poland
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Szczecin, West Pomeranian Voivodeship, Poland
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Bialystok, , Poland
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Bydgoszcz, , Poland
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Chorzów, , Poland
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Elblag, , Poland
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Katowice, , Poland
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Katowice, , Poland
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Katowice, , Poland
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Ostrowiec Świętokrzyski, , Poland
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Skarżysko-Kamienna, , Poland
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Zgierz, , Poland
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Lodz, Łódź Voivodeship, Poland
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Lodz, Łódź Voivodeship, Poland
Regeneron Study Site 3
Lodz, Łódź Voivodeship, Poland
Regeneron Study Site
Brasov, , Romania
Regeneron Study Site
Moscow, Koskva, Russia
Regeneron Study Site
Ryazan, Ryazan Oblast, Russia
Regeneron Study Site
Saint Petersburg, Sankt-Peterburg, Russia
Regeneron Study Site
Kazan', Tatarstan Respublika, Russia
Regeneron Study Site
Chelyabinsk, , Russia
Regeneron Study Site 1
Singapore, Central Singapore, Singapore
Regeneron Study Site 2
Singapore, Central Singapore, Singapore
Regeneron Study Site
Singapore, South West, Singapore
Regeneron Study Site
Košice, , Slovakia
Regeneron Study Site
Svidník, , Slovakia
Regeneron Study Site
Busan, Busan Gwang'yeogsi, South Korea
Regeneron Study Site
Bucheon-si, Kyonggi-do, South Korea
Regeneron Study Site
Hwaseong-si, Kyonggi-do, South Korea
Regeneron Study Site
Suwon, Kyonggi-do, South Korea
Regeneron Study Site
Uijeongbu-si, Kyonggi-do, South Korea
Regeneron Study Site 1
Incheon, , South Korea
Regeneron Study Site 2
Incheon, , South Korea
Regeneron Study Site 1
Seoul, , South Korea
Regeneron Study Site 2
Seoul, , South Korea
Regeneron Study Site 3
Seoul, , South Korea
Regeneron Study Site 4
Seoul, , South Korea
Regeneron Study Site 5
Seoul, , South Korea
Regeneron Study Site 6
Seoul, , South Korea
Regeneron Study Site 7
Seoul, , South Korea
Regeneron Study Site 8
Seoul, , South Korea
Regeneron Study Site
Elche, Alicante, Spain
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Badalona, Barcelona, Spain
Regeneron Study Site
Las Palmas de Gran Canaria, Canary Islands, Spain
Regeneron Study Site 1
Barcelona, , Spain
Regeneron Study Site 2
Barcelona, , Spain
Regeneron Study Site 3
Barcelona, , Spain
Regeneron Study Site 4
Barcelona, , Spain
Regeneron Study Site 1
Madrid, , Spain
Regeneron Study Site 2
Madrid, , Spain
Regeneron Study Site
Seville, , Spain
Regeneron Study Site
Dundee, Angus, United Kingdom
Regeneron Study Site
Edgbaston, Birmingham, United Kingdom
Regeneron Study Site
Plymouth, Devon, United Kingdom
Regeneron Study Site
Portsmouth, Hampshire, United Kingdom
Regeneron Study Site
Sidcup, Kent, United Kingdom
Regeneron Study Site
Northwood, London, United Kingdom
Regeneron Study Site
Oxford, Oxfordshire, United Kingdom
Regeneron Study Site
Liverpool, , United Kingdom
Regeneron Study Site 1
London, , United Kingdom
Regeneron Study Site 2
London, , United Kingdom
Regeneron Study Site
Manchester, , United Kingdom
Regeneron Study Site
Salford, , United Kingdom
Regeneron Study Site
Sheffield, , United Kingdom
Countries
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References
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Kamal MA, Kosloski MP, Lai CH, Partridge MA, Rajadhyaksha M, Kanamaluru V, Bansal A, Shabbir A, Shumel B, Ardeleanu M, Richards SM, Yan H, Xu CR, Rodriguez-Marco A, Xiao J, Khokhar FA, Gherardi G, Babilonia E, Maloney J, Mortensen E, Akinlade B, Braunstein N, Stahl N, Torri A, Davis JD, DiCioccio AT. Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis. Front Immunol. 2024 Nov 11;15:1466372. doi: 10.3389/fimmu.2024.1466372. eCollection 2024.
Blauvelt A, Wollenberg A, Eichenfield LF, Zhang H, Sierka D, Khokhar FA, Vakil J, Shabbir A, Marco AR, Cyr SL. No Increased Risk of Overall Infection in Adults with Moderate-to-Severe Atopic Dermatitis Treated for up to 4 Years with Dupilumab. Adv Ther. 2023 Jan;40(1):367-380. doi: 10.1007/s12325-022-02322-y. Epub 2022 Nov 1.
Wechsler ME, Klion AD, Paggiaro P, Nair P, Staumont-Salle D, Radwan A, Johnson RR, Kapoor U, Khokhar FA, Daizadeh N, Chen Z, Laws E, Ortiz B, Jacob-Nara JA, Mannent LP, Rowe PJ, Deniz Y. Effect of Dupilumab on Blood Eosinophil Counts in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis, or Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2022 Oct;10(10):2695-2709. doi: 10.1016/j.jaip.2022.05.019. Epub 2022 May 28.
Beck LA, Deleuran M, Bissonnette R, de Bruin-Weller M, Galus R, Nakahara T, Seo SJ, Khokhar FA, Vakil J, Xiao J, Marco AR, Levit NA, O'Malley JT, Shabbir A. Dupilumab Provides Acceptable Safety and Sustained Efficacy for up to 4 Years in an Open-Label Study of Adults with Moderate-to-Severe Atopic Dermatitis. Am J Clin Dermatol. 2022 May;23(3):393-408. doi: 10.1007/s40257-022-00685-0. Epub 2022 May 3.
Armstrong A, Blauvelt A, Simpson EL, Smith CH, Herranz P, Kataoka Y, Seo SJ, Ferrucci SM, Chao J, Chen Z, Rossi AB, Shumel B, Tomondy P. Continued Treatment with Dupilumab is Associated with Improved Efficacy in Adults with Moderate-to-Severe Atopic Dermatitis Not Achieving Optimal Responses with Short-Term Treatment. Dermatol Ther (Heidelb). 2022 Jan;12(1):195-202. doi: 10.1007/s13555-021-00643-4. Epub 2021 Dec 13.
Yosipovitch G, de Bruin-Weller M, Armstrong A, Wu JJ, Herranz P, Thaci D, Delevry D, Bagousse GB, Zhang R, Shumel B, Rossi AB, Chao J. Dupilumab Treatment Provides Sustained Improvements Over 2 Years in Symptoms and Quality of Life in Adults with Atopic Dermatitis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2147-2157. doi: 10.1007/s13555-021-00630-9. Epub 2021 Oct 29.
Beck LA, Thaci D, Deleuran M, de Bruin-Weller M, Chen Z, Khokhar FA, Zhang M, Ozturk ZE, Shumel B. Laboratory safety of dupilumab for up to 3 years in adults with moderate-to-severe atopic dermatitis: results from an open-label extension study. J Dermatolog Treat. 2022 May;33(3):1608-1616. doi: 10.1080/09546634.2020.1871463. Epub 2021 Feb 8.
Beck LA, Thaci D, Deleuran M, Blauvelt A, Bissonnette R, de Bruin-Weller M, Hide M, Sher L, Hussain I, Chen Z, Khokhar FA, Beazley B, Ruddy M, Patel N, Graham NMH, Ardeleanu M, Shumel B. Dupilumab Provides Favorable Safety and Sustained Efficacy for up to 3 Years in an Open-Label Study of Adults with Moderate-to-Severe Atopic Dermatitis. Am J Clin Dermatol. 2020 Aug;21(4):567-577. doi: 10.1007/s40257-020-00527-x.
Provided Documents
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Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Other Identifiers
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2013-001449-15
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
R668-AD-1225
Identifier Type: -
Identifier Source: org_study_id
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