Evaluation of Safety and Effectiveness of the Essure (Model ESS505) Device to Prevent Pregnancy in Women

NCT ID: NCT01948882

Last Updated: 2024-10-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

660 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2024-09-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Essure System is indicated for women who desire non-incisional permanent birth control (female sterilization) by occlusion of the fallopian tubes. The objective of the study is to evaluate the safety and effectiveness of the Essure System (Model ESS505) for permanent birth control in preventing pregnancy. The Essure ESS505 System includes a design modification that will be studied to determine if it provides immediate birth control, thereby removing the three months waiting period required for the commercially available Essure System Model 305 to be effective.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Contraception

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

ESS505

All subjects that sign the informed consent and meet the eligibility criteria will be scheduled for an implant procedure.

Group Type EXPERIMENTAL

ESS505 (BAY1454033)

Intervention Type DEVICE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ESS505 (BAY1454033)

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Female, 21 to 44 years of age, inclusive
* Body weight within range of 90-300 lbs (40 - 136 kg)
* Sexually active (minimum of 4 coital acts per cycle)
* Willing to accept the risk of pregnancy while relying solely on the inserts for contraception
* Medical history indicates bilateral viable and patent fallopian tubes
* Agrees to fulfill local requirements for counseling and consent to contraception and sterilization, including any required waiting periods

Exclusion Criteria

* Post-menopausal woman
* Suspected or confirmed pregnancy
* Post-partum or pregnancy termination ≤6 weeks of scheduled insert placement
* Past fallopian tube sterilization procedure and/or total or partial salpingectomies
* Diagnosis of any of the following: tubal, endometrial, or myometrial pathology (which may prevent fallopian tube ostia access), proximal tubal occlusion in either fallopian tube, unicornuate uterus, active or recent upper or lower pelvic infection, gynecologic malignancy
* Currently taking corticosteroids
* Known allergy to all contrast media available for use in hysterosalpingogram
* Scheduled to undergo concomitant intrauterine procedures at the time of insert placement (intrauterine device removal is not considered a concomitant procedure)
* Any general health condition or systemic disease that may represent, in the opinion of the physician, a potential increased risk associated with device use or pregnancy
Minimum Eligible Age

21 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Aurora, Colorado, United States

Site Status

Denver, Colorado, United States

Site Status

Wellington, Florida, United States

Site Status

Fort Wayne, Indiana, United States

Site Status

Newburgh, Indiana, United States

Site Status

Saginaw, Michigan, United States

Site Status

Rochester, Minnesota, United States

Site Status

New York, New York, United States

Site Status

The Bronx, New York, United States

Site Status

Asheville, North Carolina, United States

Site Status

Cincinnati, Ohio, United States

Site Status

Columbia, Ohio, United States

Site Status

Dallas, Texas, United States

Site Status

Houston, Texas, United States

Site Status

Irving, Texas, United States

Site Status

Norfolk, Virginia, United States

Site Status

Spokane, Washington, United States

Site Status

Hamilton, Ontario, Canada

Site Status

Regina, Saskatchewan, Canada

Site Status

Zwolle, , Netherlands

Site Status

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status

Córdoba, , Spain

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada Netherlands Spain

Related Links

Access external resources that provide additional context or updates about the study.

https://clinicaltrials.bayer.com/study/16973

Click here to find further information and, after study completion, the study results according to Bayer's transparency standards

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

16973

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Mirena Extension Trial
NCT02985541 COMPLETED PHASE3
European Active Surveillance Study of LCS12
NCT02146950 ACTIVE_NOT_RECRUITING