Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

NCT ID: NCT01939678

Last Updated: 2019-09-11

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 3 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2019-09-30

Brief Summary

The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification. A patient population with premature aortic valve calcification treated with aortic valve replacement will be screened for mutations in these specific genes. Furthermore, aortic valve tissue received from the operations, will be examined for the presence of Na/Pi-cotransporters, and for molecular characterization of the transporters.

Conditions

Aortic Valve Stenosis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Patients with aortic valve calcification that will be treated with an aortic valve replacement.
• Age ≤ 65 years.
• Signed and dated informed consent.

Exclusion Criteria

• Inability to provide informed consent
• Earlier radiation therapy of the thorax
• Severe renal disease (patients in treatment with dialysis)

• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Region Örebro County

OTHER

Sponsor Role: lead

Responsible Party

Ole Frobert, MD, PhD

MD, PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Department of Cardiology, Orebro University Hospital

Örebro, , Sweden

Countries

Sweden

Other Identifiers

2012-12

Identifier Type: -

Identifier Source: org_study_id