Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
NCT ID: NCT01934049
Last Updated: 2013-09-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
80 participants
INTERVENTIONAL
2013-09-30
2014-06-30
Brief Summary
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Dexmedetomidine is a drug used for sedation in critically ill patients that provides some pain relief and controls the bodies response to stress. The sedation produced by dexmedetomidine appears more similar to natural sleep than any other drug used for anesthesia and postoperative sedation. Data suggesting that dexmedetomidine can prevent delirium following cardiac surgery and the developing understanding of the causes of PD and POCD suggest that dexmedetomidine will be particularly effective.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Dexmedetomidine
Dexmedetomidine in dex group is administered as 1ug/kg by intravenous infusion 10 min and then 0.6 ug/kg until 30 minutes before the operation finishes.
hip arthroplasty
Every patient with femoral neck fractures must undergo hip hemi-arthroplasty.
Total Intravenous Anesthesia and Peripheral nerve blocks
Every patient receives Peripheral nerve blocks and Total Intravenous Anesthesia with propofol
Saline
Participants in con group receive placebo(saline) as the same dose at the same time as dex group.
hip arthroplasty
Every patient with femoral neck fractures must undergo hip hemi-arthroplasty.
Total Intravenous Anesthesia and Peripheral nerve blocks
Every patient receives Peripheral nerve blocks and Total Intravenous Anesthesia with propofol
Interventions
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hip arthroplasty
Every patient with femoral neck fractures must undergo hip hemi-arthroplasty.
Total Intravenous Anesthesia and Peripheral nerve blocks
Every patient receives Peripheral nerve blocks and Total Intravenous Anesthesia with propofol
Eligibility Criteria
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Inclusion Criteria
* Patients with femoral neck fractures
* Undergoing hip hemi-arthroplasty surgery
* American Society of Anesthesiologists (ASA) physical status II-IV
* MoCA being more than 23
Exclusion Criteria
* Patient refusal or failure of regional block
* allergic to local anesthetics or general anesthetics
* history of opioid dependence
* contraindications to nerve blocks (coagulation defects, infection at puncture site, preexisting neurological deficits in the lower extremities)
* current severe psychiatric disease or alcoholism or drug dependence
* severe visual or auditory disorder
75 Years
ALL
No
Sponsors
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Chinese PLA General Hospital
OTHER
Responsible Party
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Junle Liu
Principal Investigator
Principal Investigators
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zhang hong, ph.d
Role: STUDY_CHAIR
Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital
Locations
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Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital
Beijing, , China
Countries
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Central Contacts
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yuan weixiu, ph.d
Role: CONTACT
Facility Contacts
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Zhang Hong, ph.d
Role: primary
Yuan Weixiu, Ph.d
Role: backup
Other Identifiers
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Dex-THR
Identifier Type: -
Identifier Source: org_study_id