Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes

NCT ID: NCT01926938

Last Updated: 2013-08-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 44 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2003-05-31
• Study Completion Date: 2013-01-31

Brief Summary

Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with diabetes. Endothelial function and vascular reactivity are impaired not only in white adults with type 2 diabetes but also in those at risk for the disease by virtue of having impaired glucose tolerance or parental history of type 2 diabetes. Whether this finding is applicable to hispanics is not known. The investigators plan to assess the endothelial function and vascular reactivity in young Hispanic adults at risk of developing type 2 diabetes by virtue of being obese and belonging to a minority population.

Conditions

Obesity; Insulin Resistance

Study Design

• Study Time Perspective: CROSS_SECTIONAL

Study Groups

adults at risk

Latino adults with family history of type 2 diabetes

No interventions assigned to this group

controls

Latino adults without family history of type 2 diabetes and normal glucose tolerance

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Group 1:

1. Age between 18-40 years;

2. Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");

3. History of type 2 diabetes in one or both parents;

4. BMI above 27;

5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Group 2:

1. Age between 18-40 years;

2. Hispanic (same criteria as above );

3. No history of type 2 diabetes in any first degree relative;

4. BMI under 25;

5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Exclusion Criteria

• diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Joslin Diabetes Center

OTHER

Sponsor Role: lead

Responsible Party

Enrique Caballero

Clinical Investigator/Director, Latino Diabetes Initiative

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Enrique Caballero, MD

Role: PRINCIPAL_INVESTIGATOR

Joslin Diabetes Center

Locations

Joslin Diabetes Center

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

CHS#: 03-30

Identifier Type: -

Identifier Source: org_study_id