Effect of Dexmedetomidine on QT Interval in Pediatric Patients Under General Anesthesia

NCT ID: NCT01917786

Last Updated: 2016-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-02-28

Brief Summary

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Various medications used in anesthesia have been implicated in the prolongation of QT interval. Recently, there has been an increase in the use of dexmedetomidine in patients presenting for surgeries given its beneficial sedative, anxiolytic, and analgesic properties. It has several desirable properties including minimal respiratory side effects as well as the ability to decrease intraoperative and postoperative analgesic requirements. In many of the patients who present for routine surgical procedures, dexmedetomidine is a common component of their anesthetic care. This is a study to assess the effects of dexmedetomidine on the QT interval in children presenting for surgery.

Detailed Description

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Conditions

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Surgery

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Dexmedetomidine patients

Surgical patients receiving dexmedetomidine.

ECG

Intervention Type DEVICE

Control patients

Surgical patients not receiving dexmedetomidine.

ECG

Intervention Type DEVICE

Interventions

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ECG

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* ASA grade 1 or 2.
* Scheduled to receive dexmedetomidine.

Exclusion Criteria

* Known allergy to dexmedetomidine.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Senthil G. Krishna

OTHER

Sponsor Role lead

Responsible Party

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Senthil G. Krishna

Assistant Clinical Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status

Countries

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United States

References

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Kako H, Krishna SG, Sebastian R, Smith K, Tobias JD. Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia. J Anesth. 2015 Dec;29(6):862-7. doi: 10.1007/s00540-015-2056-2. Epub 2015 Aug 4.

Reference Type DERIVED
PMID: 26238761 (View on PubMed)

Other Identifiers

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IRB13-00171

Identifier Type: -

Identifier Source: org_study_id

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