Ridge Augmentation Without Primary Closure

NCT ID: NCT01901783

Last Updated: 2016-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-06-30

Brief Summary

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This study is designed to compare the clinical and histologic results of ridge augmentation with and without primary closure over the barrier membrane. The hypothesis is that there will be no difference in crestal ridge width between the two groups.

Detailed Description

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A maximum of 30 patients will be selected that meet the following criteria:

Inclusion Criteria

1. At least a one tooth area with a ridge defect, treatment planned to receive a dental implant. The site must be bordered by at least one tooth.
2. Healthy person that is at least 18 years old.
3. Patient understands and signs an informed consent approved by the University of Louisville Human Studies Committee.

Exclusion Criteria

1. Patients with debilitating systemic diseases, diseases that affect the periodontium, or psychological problems that would interfere with treatment.
2. Previous head and neck radiation or chemotherapy within the previous 12 months.
3. Patients with known allergy to any of the materials that will be used in the study.
4. Smokers.
5. Patients who need prophylactic antibiotics prior to dental procedures.
6. Patients on long-term steroid therapy or oral bisphosphonates \> 3 years or any IV biosphosphonates.
7. Patients who are pregnant.

Conditions

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Alveolar Ridge Augmentation

Keywords

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allograft regeneration alveolar ridge

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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With primary closure

The ridge augmentation graft will be covered with a barrier membrane and the soft tissue will be primarily closed.

Group Type ACTIVE_COMPARATOR

With primary closure

Intervention Type PROCEDURE

A cancellous block allograft will be placed for ridge augmentation and covered with a barrier membrane. The soft tissue will be primarily closed over the membrane.

Without primary closure

The ridge augmentation graft will be covered with a barrier membrane and the soft tissue will not be primarily closed.

Group Type EXPERIMENTAL

Without primary closure

Intervention Type PROCEDURE

A cancellous block allograft will be placed for ridge augmentation and covered with a barrier membrane. The soft tissue will not be primarily closed over the membrane.

Interventions

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With primary closure

A cancellous block allograft will be placed for ridge augmentation and covered with a barrier membrane. The soft tissue will be primarily closed over the membrane.

Intervention Type PROCEDURE

Without primary closure

A cancellous block allograft will be placed for ridge augmentation and covered with a barrier membrane. The soft tissue will not be primarily closed over the membrane.

Intervention Type PROCEDURE

Other Intervention Names

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Primary soft tissue closure over the membrane. No primary soft tissue closure over the membrane.

Eligibility Criteria

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Inclusion Criteria

1. At least a one tooth area with a ridge defect, treatment planned to receive a dental implant. The site must be bordered by at least one tooth.
2. Healthy person that is at least 18 years old.
3. Patient understands and signs an informed consent approved by the University of Louisville Human Studies Committee.

Exclusion Criteria

1. Patients with debilitating systemic diseases, diseases that affect the periodontium, or psychological problems that would interfere with treatment.
2. Previous head and neck radiation or chemotherapy within the previous 12 months.
3. Patients with known allergy to any of the materials that will be used in the study.
4. Smokers.
5. Patients who need prophylactic antibiotics prior to dental procedures.
6. Patients on long-term steroid therapy or oral bisphosphonates \> 3 years or any IV biosphosphonates.
7. Patients who are pregnant.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Louisville

OTHER

Sponsor Role lead

Responsible Party

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Henry Greenwell

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Henry Greenwell, DMD

Role: PRINCIPAL_INVESTIGATOR

University of Louisville

Locations

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Graduate Periodontics Clinic University of Louisville

Louisville, Kentucky, United States

Site Status

Countries

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United States

Other Identifiers

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13.0331

Identifier Type: -

Identifier Source: org_study_id