Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

NCT ID: NCT01891942

Last Updated: 2013-07-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2013-06-30

Brief Summary

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The inspiratory pressure trigger is essential when assessing the twitch mouth pressure (Tw Pmo) for avoiding glottic closure. However, the difference in inspiratory pressure trigger threshold may influence the values of Tw Pmo. We sought to determine the trigger threshold for healthy subjects and COPD patients.

Detailed Description

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Conditions

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COPD Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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COPD patients

All of the COPD patients included in this study were stable with no episodes of exacerbation within the previous 2 months. Patients with COPD were not currently being treated with oral corticosteroids.

Group Type EXPERIMENTAL

twitch by magstim

Intervention Type PROCEDURE

normal subjects

Fifteen healthy men with normal lung function

Group Type EXPERIMENTAL

twitch by magstim

Intervention Type PROCEDURE

Interventions

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twitch by magstim

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Clinical diagnosis of COPD
2. Stable with no episodes of exacerbation within the previous 2 months
3. Do not currently being treated with oral corticosteroids

Exclusion Criteria

1. Not stable within the previous 2 months.
2. Patients with COPD were currently being treated with oral corticosteroids
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Guangzhou Institute of Respiratory Disease

OTHER

Sponsor Role lead

Responsible Party

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DM Hua

Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rong-chang Chen, Master

Role: STUDY_CHAIR

Guangzhou Instiute of Respiratory Disease

Dong-ming Hua, Master

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Institue of Respiratory Disease

Nan-shan Zhong, Bachelor

Role: STUDY_CHAIR

Guangzhou Institue of Respiratory Disease

Locations

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Guangzhou Institute Respiratory Disease

Guangzhou, Guangdong, China

Site Status

Countries

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China

References

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Walker DJ, Ertl T, Walterspacher S, Schlager D, Roecker K, Windisch W, Kabitz HJ. Respiratory muscle function during a six-week period of normocapnic hyperpnoea training. Respir Physiol Neurobiol. 2013 Aug 15;188(2):208-13. doi: 10.1016/j.resp.2013.05.005. Epub 2013 May 17.

Reference Type RESULT
PMID: 23689008 (View on PubMed)

Hua DM, Liang YH, Xie YK, Liu Q, Zheng ZG, Chen RC, Zhong NS. Use of twitch mouth pressure to assess diaphragm strength in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2013 Jul 1;187(3):211-6. doi: 10.1016/j.resp.2013.04.012. Epub 2013 Apr 15.

Reference Type RESULT
PMID: 23597835 (View on PubMed)

Other Identifiers

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GIRD-566

Identifier Type: REGISTRY

Identifier Source: secondary_id

GIRD-566

Identifier Type: -

Identifier Source: org_study_id

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