Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

56 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2017-10-31

Brief Summary

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Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown.

Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis.

Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days.

During the evaluation the following tests will be done:

* Anthropometric measures
* Level of daily physical activity
* Pulmonary function test
* Maximal incremental cardiopulmonary exercise test on ergocycle
* Endurance test on ergocycle
* Muscle function tests
* Magnetic stimulation
* Quadriceps biopsy

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Detailed Description

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Conditions

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Non-Small-cell Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lung cancer patient with cachexia

Muscle lumbar area \< 55cm2/m2 for men and \< 39 cm2/m2 for women

No interventions assigned to this group

Lung cancer patients without cachexia

Muscle lumbar area over 55cm2/m2 for men and 39 cm2/m2 for women

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Men and women with a primary lung cancer diagnosis

Exclusion Criteria

* Already have undertaken surgery, chemotherapy or radiotherapy treatment
* Having an other cancer in the last five years
* Taking anticoagulation therapy

Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes