Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
NCT ID: NCT01873612
Last Updated: 2016-02-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
11 participants
INTERVENTIONAL
2013-05-31
2014-09-30
Brief Summary
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Detailed Description
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6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Sedation with dexmedetomidine
Sedation with dexmedetomidine
Hypoxic ventilatory response
Hypercapnic ventilatory response
Sedation with propofol
Sedation with propofol
Hypoxic ventilatory response
Hypercapnic ventilatory response
Interventions
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Hypoxic ventilatory response
Hypercapnic ventilatory response
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Age 18-40
3. American Society of Anesthesiologist´s classification (ASA) 1, i.e. healthy
4. No medication
5. No allergies
6. Non-smoker/no snuff, i.e. no nicotine intake
7. Normal weight, BMI \<26
Exclusion Criteria
18 Years
40 Years
MALE
Yes
Sponsors
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Karolinska University Hospital
OTHER
Responsible Party
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Malin Jonsson Fagerlund
MD, PhD
Principal Investigators
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Malin Jonsson Fagerlund, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Karolinska University Hospital and Karolinska Institutet
Locations
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Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital
Stockholm, , Sweden
Countries
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Other Identifiers
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PropDexHVRVolunteers
Identifier Type: -
Identifier Source: org_study_id
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