Vitamin D3, Folic Acid and Fexofenadine in Healthy Volunteers

NCT ID: NCT01856348

Last Updated: 2013-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2013-07-31

Brief Summary

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The study is conducted to assess the effect of a vitamin D3 supplementation on the activities of two intestinal transporters and on the pharmacokinetics of the transporter substrates folic acid and fexofenadine.

* Trial with medicinal product

Detailed Description

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Conditions

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Physiological Effects of Vitamin D

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1, 25 dihydroxyvitamin D3 intake

This is a single arm study.

Group Type EXPERIMENTAL

Vitamin D

Intervention Type DRUG

Interventions

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Vitamin D

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. male or female
2. age 18 to 65 years at study entry
3. signed informed consent form
4. Body Mass Index \> 18 - \< 30 kg/m2
5. Participants must not have any other diseases (as assessed by the screening examination)
6. Participants must not take any concomitant medications except oral contraceptives in females
7. Normal blood count

Exclusion Criteria

1. Subjects with confirmed or suspected hypersensitivity towards the study medications
2. Contemporaneous participation in any other study
3. Females only: pregnancy
4. Females only: breast-feeding
5. Clinically significant abnormal laboratory findings
6. Known or suspected present or past malignancies of any kind
7. Known or suspected active infections, serious infections in the preceding 3 months
8. Positive hepatitis B, hepatitis C and / or HIV 1/2 serology
9. Subjects known or suspected not to comply with the study regulations
10. Subjects employed at the participating departments of the University Hospital Zürich.
11. Known or suspected present or past diseases which may interfere with the study
12. smokers
13. alcohol or drug abuse
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gerd A Kullak-Ublick, Prof MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Pharmacology and Toxicology

Locations

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University Hospital Zurich, Dept. of Clinical Pharmacology and Toxicology

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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PHA-11-VID/FOL-01

Identifier Type: -

Identifier Source: org_study_id