Supplementation of Land-based Stearidonic Acid (SDA)-Rich Oils in Humans
NCT ID: NCT01856179
Last Updated: 2013-05-17
Study Results
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Basic Information
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COMPLETED
EARLY_PHASE1
78 participants
INTERVENTIONAL
2011-03-31
2012-04-30
Brief Summary
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Detailed Description
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One approach involves searching for potential vegetable sources of n-3 PUFA; especially those rich in ALA and SDA. The conversion of ALA to SDA in humans depends on the rate-limiting ∆6-desaturation. Plant-derived SDA is therefore a promising precursor regarding endogenous synthesis of n-3 LC-PUFA in humans. The enrichment of n-3 LC-PUFA in human lipids during the supplementation of ALA- and SDA-rich Echium oil will be compared with SDA-rich soybean oil.
Eighty volunteers will be recruited and allocated into four study groups depending on age and BMI. Three groups (each n=20) will receive daily ca. 20 g Echium oil ( group 1 and 2: mean BMI \< 25, with mean age: 25 or 55 years; group 3: mean age 55 and BMI \> 25). One group (n=20) will receive SDA soybean oil ( dose with comparable amount of SDA; BMI \< 25; mean age 25 and 55). The double-blind, randomized, parallel-designed study will start with a two-weeks run-in period, followed by an eight-weeks supplementation period. After the run-in period, one week and eight weeks of oil supplementation blood will be drawn and 24-h urine will be sampled.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Echium oil young
BMI\<25,
age 20-30
Echium oil
Oil of Echium platagineum (natural plant oil) ca. 15-18 g/d (Croda)
Echium oil older
age 40-70 BMI \<25
Echium oil
Oil of Echium platagineum (natural plant oil) ca. 15-18 g/d (Croda)
Echium oil older, overweight
age 40-70 BMI \>25
Echium oil
Oil of Echium platagineum (natural plant oil) ca. 15-18 g/d (Croda)
Interventions
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Echium oil
Oil of Echium platagineum (natural plant oil) ca. 15-18 g/d (Croda)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* chronic diseases
* pregnancy, lactation
* intake of nutritional supplements
20 Years
70 Years
ALL
Yes
Sponsors
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German Research Foundation
OTHER
University of Jena
OTHER
Responsible Party
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Gerhard Jahreis
Prof. Dr. habil.
Principal Investigators
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Katrin Kuhnt, Dr. rer. nat
Role: PRINCIPAL_INVESTIGATOR
University of Jena, Insitute of Nutrition
Locations
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Friedrich Schiller University of Jena
Jena, Thuringia, Germany
Countries
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References
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Kuhnt K, Weiss S, Kiehntopf M, Jahreis G. Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. Lipids Health Dis. 2016 Feb 18;15:32. doi: 10.1186/s12944-016-0199-2.
Kuhnt K, Fuhrmann C, Kohler M, Kiehntopf M, Jahreis G. Dietary echium oil increases long-chain n-3 PUFAs, including docosapentaenoic acid, in blood fractions and alters biochemical markers for cardiovascular disease independently of age, sex, and metabolic syndrome. J Nutr. 2014 Apr;144(4):447-60. doi: 10.3945/jn.113.180802. Epub 2014 Feb 19.
Other Identifiers
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LSEP H42-KK
Identifier Type: -
Identifier Source: org_study_id
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