Prometra Post-Approval Study

NCT ID: NCT01854229

Last Updated: 2023-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-20

Study Completion Date

2023-03-15

Brief Summary

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The Prometra Pump is approved by the FDA for use in the United States. The purpose of this study is to collect long-term safety data on the Prometra Pump.

Detailed Description

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This study is proposed under part of the post-Premarket Approval (PMA) requirements. This study is a prospective, non-randomized, open-label, multicenter study. It will be performed at 10-30 centers in the US and enroll a maximum of 400 subjects. Subjects will be followed for a total of five years.

Conditions

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Chronic Pain Cancer Pain Intractable Pain Back Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Prospective pump candidates

New candidates who will receive the Prometra Programmable Intrathecal Infusion Pump

Group Type ACTIVE_COMPARATOR

Prometra Programmable Intrathecal Infusion Pump

Intervention Type DEVICE

There are two enrollment groups (arms). One is for new patients who are going to have a Prometra Pump implanted. The other arm is for patients who were part of the IDE study prior to FDA approval of the pump, and are willing to continue to be followed as part of a study.

Previous IDE study subjects continuing with the therapy

Patients who were part of the previous IDE study, still have an active Prometra Programmable Intrathecal Infusion Pump, and are willing to continue in a study protocol.

Group Type ACTIVE_COMPARATOR

Prometra Programmable Intrathecal Infusion Pump

Intervention Type DEVICE

There are two enrollment groups (arms). One is for new patients who are going to have a Prometra Pump implanted. The other arm is for patients who were part of the IDE study prior to FDA approval of the pump, and are willing to continue to be followed as part of a study.

Interventions

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Prometra Programmable Intrathecal Infusion Pump

There are two enrollment groups (arms). One is for new patients who are going to have a Prometra Pump implanted. The other arm is for patients who were part of the IDE study prior to FDA approval of the pump, and are willing to continue to be followed as part of a study.

Intervention Type DEVICE

Other Intervention Names

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Flowonix pump

Eligibility Criteria

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Inclusion Criteria

1. Patient meets at least one of the following:

* is suffering from malignant pain (i.e., cancer pain)
* has chronic, non-malignant pain
* subject was enrolled in PUMP I or PUMP II study and chooses to participate in this Post-Approval study
* Patient with an existing implantable pump for pain therapy that requires replacement
2. Patient is at least 22 years of age.
3. Investigator considers the patient to be able and willing to fulfill all study requirements.
4. Patient has provided written informed consent to participate in the study.

Exclusion Criteria

1. Patient meets any of the contraindications for use of the Prometra System
2. Patient has a prior history of granuloma formation, or is receiving treatment for a suspected granuloma.
3. Patient is pregnant or breast-feeding or is of child-bearing potential and not employing effective birth control.
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Flowonix Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cory Brantley

Role: STUDY_DIRECTOR

Flowonix Medical

Locations

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Perlman Clinic

La Jolla, California, United States

Site Status

Pacific Pain Physicians

Santa Barbara, California, United States

Site Status

Evolve Restorative Center

Santa Barbara, California, United States

Site Status

Summit Pain Alliance

Santa Rosa, California, United States

Site Status

BioHealth Pain Management

Torrance, California, United States

Site Status

Interventional Pain Management

Daytona Beach, Florida, United States

Site Status

Florida Institute of Medical Research

Jacksonville, Florida, United States

Site Status

Palm Beach Pain Management

Lake Worth, Florida, United States

Site Status

Pain Institute of Tampa

Tampa, Florida, United States

Site Status

Global Scientific Innovations

Evansville, Indiana, United States

Site Status

Summit Pain Management

Fort Wayne, Indiana, United States

Site Status

Summit Research Institute

Fort Wayne, Indiana, United States

Site Status

Interventional Pain Management Specialists

Overland Park, Kansas, United States

Site Status

Bluegrass Pain Consultants

Louisville, Kentucky, United States

Site Status

Kentuckiana Pain Specialists

Louisville, Kentucky, United States

Site Status

Neuroscience and Pain Institute

Covington, Louisiana, United States

Site Status

Integrated Pain and Neuroscience

New Orleans, Louisiana, United States

Site Status

Jackson Anesthesia Pain Center

Jackson, Mississippi, United States

Site Status

Triumph Medical

Asheville, North Carolina, United States

Site Status

Integrated Pain Solutions

Columbus, Ohio, United States

Site Status

Pain Management Institute

Wooster, Ohio, United States

Site Status

Neurospine Institute

Eugene, Oregon, United States

Site Status

Pain Care of Oregon

Medford, Oregon, United States

Site Status

Fox Chase Pain Management Associates

Trevose, Pennsylvania, United States

Site Status

Space City Pain Specialists

Webster, Texas, United States

Site Status

Nexus Pain Care

Provo, Utah, United States

Site Status

Countries

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United States

References

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Rauck R, Deer T, Rosen S, Padda G, Barsa J, Dunbar E, Dwarakanath G. Long-term follow-up of a novel implantable programmable infusion pump. Neuromodulation. 2013 Mar-Apr;16(2):163-7. doi: 10.1111/j.1525-1403.2012.00515.x. Epub 2012 Oct 11.

Reference Type BACKGROUND
PMID: 23057877 (View on PubMed)

Related Links

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http://www.painmed.org/

American Academy of Pain Medicine

http://www.neuromodulation.org/

North American Neuromodulation Society

http://www.asra.com/

American Society of Regional Anesthesia and Pain Medicine

Other Identifiers

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PAS-01

Identifier Type: -

Identifier Source: org_study_id

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