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Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity

NCT ID: NCT01847456

Last Updated: 2013-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Brief Summary

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The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.

Detailed Description

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Conditions

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Insulin Sensitivity

Keywords

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whole body insulin sensitivity insulin action in the brain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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insulin nasal spray

160 Units of human insulin as nasal spray

Group Type EXPERIMENTAL

human insulin as nasal spray

Intervention Type DRUG

Placebo nasal spray

Nasalspray containing placebo solution

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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human insulin as nasal spray

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* BMI \< 28 kg/m2
* normal HbA1c
* healthy volunteers

Exclusion Criteria

* Heparin induced thrombocytopenia (HIT)
* metal implants
* cardial diseases
* anemia
* patients taking any kind of drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital Tuebingen

OTHER

Sponsor Role lead

Responsible Party

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andreas fritsche

Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Tuebingen, Internal medicine IV

Tübingen, , Germany

Site Status

Countries

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Germany

References

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Heni M, Wagner R, Kullmann S, Veit R, Mat Husin H, Linder K, Benkendorff C, Peter A, Stefan N, Haring HU, Preissl H, Fritsche A. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes. 2014 Dec;63(12):4083-8. doi: 10.2337/db14-0477. Epub 2014 Jul 15.

Reference Type DERIVED
PMID: 25028522 (View on PubMed)

Other Identifiers

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SFB 997 A01 WP7

Identifier Type: -

Identifier Source: org_study_id