The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
NCT ID: NCT01843855
Last Updated: 2013-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
12 participants
INTERVENTIONAL
2011-06-30
2013-09-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Exendin 9,39
Subjects randomized to this arm will receive an infusion of exendin 9,39 of 300mmol/kg/min for 360 minutes.
Exendin 9,39
Exendin 9,39 is a competitive antagonist of endogenous GLP-1.
Placebo
Subjects randomized to this arm will receive a saline infusion for 360 minutes.
Placebo
A saline infusion will be given to match the study drug infusion.
Interventions
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Exendin 9,39
Exendin 9,39 is a competitive antagonist of endogenous GLP-1.
Placebo
A saline infusion will be given to match the study drug infusion.
Eligibility Criteria
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Inclusion Criteria
* Subjects registered to receive a Roux-en-Y Gastric Bypass (RYGB).
Exclusion Criteria
* Subjects with active systemic illness
* Subjects with active microvascular or macrovascular complications of their diabetes
* For female subject: positive pregnancy test at the time of enrollment in study
20 Years
65 Years
ALL
No
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
National Center for Research Resources (NCRR)
NIH
Adrian Vella
OTHER
Responsible Party
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Adrian Vella
Consultant, Endocrinology
Principal Investigators
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Adrian Vella, M.D.
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic
Rochester, Minnesota, United States
Countries
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Other Identifiers
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