Serum Biomarker of Plaque Vulnerability and Contrast Ultrasound of Carotid Artery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2013-12-31

Brief Summary

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No serum biomarker has qualified for clinical use until now. However several biomarkers, especially markers of inflammatory or proteolytic activity seem to promising in the identification of vulnerable plaques. Moreover, recent study confirmed that contrast-enhanced ultrasound imaging(CEUS) can visualize intraplaque neovascularization and represent the plaque vulnerability. In this study we try to identify indicators through analysis of the relationship between plaque neovascularization seen by CEUS and well known biomarkers such as serum matrix metalloproteinase(MMP)-2, MMP-9, cathepsin family(L,S,V), cystatin C, lipoprotein phospholipase A2, and hs-crp

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Detailed Description

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Conditions

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Intraplaque Neovascularization Evaluated by Carotid Enhanced Ultrasound Well Reflect the Plaque Vulnerability

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients with carotid plaques size more than 2mm by carotid ultrasound

Exclusion Criteria

* known allergy to albumin, or to the ultrasound contrast agent
* the patients with history of carotid endarterectomy and carotid stent
* acute myocardial infarction, cardiogenic shock
* connective tissue disease and malignancy
* creatinine clearance lower than 30ml/min and the history of dialysis

Eligible Sex

ALL

Accepts Healthy Volunteers

No