Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis

NCT ID: NCT01837615

Last Updated: 2015-06-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2015-06-30

Brief Summary

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Low Level Light therapy (LLLT) has been used for tissue healing in many mucosal diseases that involve wounds, ulcers and inflammation, oral chemotherapy-induced mucositis in particular. Likewise IBD is characterized by chronic tissue inflammation, tissue damage and ulcerations in various extents. Therefore we hypothesize that LLLT might be effective in treating IBD and the Photopill capsule was developed for this purpose.

An open-label, interventional, clinical trial was designed for assessment of the safety and feasibilty of the Photopill capsule treatment in patients with mild to moderate Ulcerative Proctitis.

Primary endpoints being: safety reflected by the number and severity of adverse events and mucosal appearance at sigmoidoscopies day 14, day 28, day 42 compared to baseline condition.

Furthermore clinical and biochemical parameters are monitored during the study.

Detailed Description

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Conditions

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Ulcerative Colitis Proctitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Photopill treatment

Group Type EXPERIMENTAL

Photopill treatment

Intervention Type DEVICE

Interventions

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Photopill treatment

Intervention Type DEVICE

Other Intervention Names

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Photopill

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with Ulcerative Proctitis (Mayo grade 1/2)

Exclusion Criteria

* Symptomatic hemorrhoids
* Pregnant or lactating females
* Patients that have used any experimental treatment within 8 weeks prior to Day 0
* Patient that have used any biologics therapies or immunomodulation agents and/or steroids 4 weeks prior to Day 0
* Rectal therapy 2 weeks prior to Day 0
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Photopill Medical Ltd

UNKNOWN

Sponsor Role collaborator

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

Sponsor Role lead

Responsible Party

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Hanke Brandse

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Geert R D'Haens, MD

Role: PRINCIPAL_INVESTIGATOR

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Locations

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Academic Medical Center

Amsterdam, North Holland, Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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NL39583.018.12

Identifier Type: -

Identifier Source: org_study_id

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