Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I
NCT ID: NCT01834989
Last Updated: 2020-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
40 participants
INTERVENTIONAL
2013-04-30
2020-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Insulin-like growth factor I
3 injection (1 mg), once a week the first 3 weeks of the 12 weeks of intervention
Insulin-like growth factor I
Placebo injections
3 Injections of saline into the patellar tendon 3 times during the first 3 weeks of the 12 weeks interventions period
Placebo
Interventions
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Insulin-like growth factor I
Placebo
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* anterior-posterior thickening of the tendon (1 mm compared to mid-tendon)
* hypo-echoic area with enhanced vascularization
Exclusion Criteria
* Knee operation
* Knee osteoarthritis
* Diabetes
* Smoking
* Body mass index \>30
18 Years
50 Years
ALL
No
Sponsors
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The Danish Medical Research Council
OTHER
Bispebjerg Hospital
OTHER
Responsible Party
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Mette Hansen
Associated Professor, PhD
Principal Investigators
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Michael Kjaer, Professor
Role: PRINCIPAL_INVESTIGATOR
Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark
Mette Hansen, PhD
Role: PRINCIPAL_INVESTIGATOR
Section of Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000 Aarhus C, Denmark
Jens Olesen, PhD
Role: PRINCIPAL_INVESTIGATOR
Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, 2400 Copenahagen, Denmark
Locations
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Institute of Sports Medicine, Copenhagen
Copenhagen, , Denmark
Countries
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References
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Olesen JL, Hansen M, Turtumoygard IF, Hoffner R, Schjerling P, Christensen J, Mendias CL, Magnusson PS, Kjaer M. No Treatment Benefits of Local Administration of Insulin-like Growth Factor-1 in Addition to Heavy Slow Resistance Training in Tendinopathic Human Patellar Tendons: A Randomized, Double-Blind, Placebo-Controlled Trial With 1-Year Follow-up. Am J Sports Med. 2021 Jul;49(9):2361-2370. doi: 10.1177/03635465211021056. Epub 2021 Jun 17.
Related Links
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Study location
Other Identifiers
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H-4-2012-078
Identifier Type: -
Identifier Source: org_study_id
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