French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS)

NCT ID: NCT01831128

Last Updated: 2021-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

509 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-11-30

Study Completion Date

2020-09-30

Brief Summary

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The purpose of FACE study is to provide in routine practice complementary long-term data on the mortality and morbidity of Chronic Heart Failure (CHF) patients with Central Sleep Apnea eligible for Adaptative Servo-Ventilation (ASV) treatment (PaceWave, AutoSet CS; ResMed).

Detailed Description

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The prevalence of Central Sleep Apnea (CSA) and/or Cheyne-Stokes Respiration (CSR) in patients with Chronic Heart Failure (HF) is 15-46% and it is associated with worse prognosis. Adaptative Servo-Ventilation (ASV) suppresses sleep apnoea and reduces hyperventilation, and is more effective than continuous positive airway pressure (CPAP) for treating CSA/CSR. Short-term studies show that ASV improves cardiac function and quality of life in CHF patients.

The SERVE HF multinational randomized trial is assessing the effects of addition of ASV (PaceWave, AutoSet CS; ResMed) to optimal medical management compared with medical management alone in symptomatic CHF patients with altered Left Ventricular Ejection Fraction and predominant CSA/CSR. The FACE study is a French prospective, multicentre, observational cohort that will provide complementary data to SERVE HF trial by characterizing CHF population eligible for ASV indications and evaluating the treatment management on long term follow-up of CHF patients with CSA/CSR in routine practice.

Conditions

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Chronic Heart Failure Central Sleep Apnea

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ASV Treatment

AutoSet CS, PaceWave

ASV Treatment

Intervention Type DEVICE

Control

No ASV treatment

No interventions assigned to this group

Interventions

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ASV Treatment

Intervention Type DEVICE

Other Intervention Names

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PaceWave AutoSet CS

Eligibility Criteria

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Inclusion Criteria

* Adult Patient with Chronic Heart Failure
* Central Sleep Apnea requiring ASV therapy

Exclusion Criteria

* Contra-indications to ASV therapy
* Respiratory Failure or Hypercapnia inconsistent with ASV therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ResMed

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marie-Pia d'ORTHO, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

APHP (Assistance Publique Hôpitaux de Paris) - Bichat-Claude Bernard Hospital, Paris

Jean-Louis PEPIN, MD, PhD

Role: STUDY_CHAIR

Grenoble University Hospital, Grenoble

Jean-Marc DAVY, MD, PhD

Role: STUDY_CHAIR

Arnaud de Villeneuve University Hospital, Montpellier

Thibaud DAMY, MD, PhD

Role: STUDY_CHAIR

APHP - Henri Mondor University Hospital, Creteil

Patrick LEVY, MD, PhD

Role: STUDY_CHAIR

Grenoble University Hospital, Grenoble

Renaud TAMISIER, MD, PhD

Role: STUDY_CHAIR

Grenoble University Hospital, Grenoble

Locations

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Medical practice of cardiology

Amnéville, , France

Site Status

Angers University Hospital

Angers, , France

Site Status

Antibes Hospital

Antibes, , France

Site Status

Béziers Hospital

Béziers, , France

Site Status

Cannes Hospital

Cannes, , France

Site Status

Henri-Mondor University Hospital

Créteil, , France

Site Status

Grenoble University Hospital

Grenoble, , France

Site Status

Le Mans Hospital

Le Mans, , France

Site Status

HCL - Croix-Rousse Hospital

Lyon, , France

Site Status

Jacques Cartier Hospital

Massy, , France

Site Status

Arnaud de Villeneuve University Hospital

Montpellier, , France

Site Status

Nevers Hospital

Nevers, , France

Site Status

APHP - Pitié-Salpêtrière University Hospital

Paris, , France

Site Status

APHP - Bichat-Claude Bernard Hospital

Paris, , France

Site Status

Bordeaux University Hospital

Pessac, , France

Site Status

Poitiers University Hospital

Poitiers, , France

Site Status

Saint Laurent Polyclinic

Rennes, , France

Site Status

Toulouse University Hospital

Toulouse, , France

Site Status

Countries

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France

References

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Tamisier R, Damy T, Bailly S, Goutorbe F, Davy JM, Lavergne F, Palot A, Verbraecken JA, d'Ortho MP, Pepin JL; FACE investigators; Steering committee members; d'Ortho MP, Pepin JL, Davy JM, Damy T, Tamisier R; FACE study investigators. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort. Sleep Med. 2024 Jan;113:412-421. doi: 10.1016/j.sleep.2023.07.014. Epub 2023 Jul 22.

Reference Type DERIVED
PMID: 37612192 (View on PubMed)

Tamisier R, Damy T, Davy JM, Verbraecken JA, Bailly S, Lavergne F, Palot A, Goutorbe F, Pepin JL, d'Ortho MP. Cohort profile: FACE, prospective follow-up of chronic heart failure patients with sleep-disordered breathing indicated for adaptive servo ventilation. BMJ Open. 2020 Jul 19;10(7):e038403. doi: 10.1136/bmjopen-2020-038403.

Reference Type DERIVED
PMID: 32690535 (View on PubMed)

Other Identifiers

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FACE 001

Identifier Type: -

Identifier Source: org_study_id

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