Epidemiological Analysis of Vitamin D and Breast Cancer Risk in Saudi Arabian Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-05-31

Study Completion Date

2009-08-31

Brief Summary

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This is an analysis of de-identified data collected from 240 Saudi Arabian women, 120 with breast cancer and 120 control women, to evalyate if vitamin D status is associated with breast cancer risk.

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Detailed Description

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Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian women are thought to be at greater risk for vitamin D deficiency due to darker skin type and greater likelihood for reduced UVB radiation exposure. However, there is a lack of data regarding the vitamin D status of Saudi Arabian women and how this may relate to breast cancer risk.

Objective: The purpose of this research was to evaluate the association between circulating concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women.

Design: A case-control study was conducted among 120 breast cancer cases and 120 controls. The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi Arabia from June to August 2009. Participants completed questionnaires on diet and medical history and serum samples were collected from all women to measure circulating 25(OH)D concentrations.

Conditions

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Breast Cancer Vitamin D Deficiency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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breast cancer cases

breast cancer cases versus controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Invasive breast cancer (cases) or healthy women (controls),
* receiving standard medical check-ups at the women's clinic
* Female,
* between the ages of 18 and 75 years
* BMI ≤ 40 kg/m2
* residence in Saudi Arabia for more than 5 years
* absence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.

Exclusion Criteria

receiving standard medical check-ups at the women's clinic

* Male,
* less than 18 or greater than 75 years of age
* BMI \> 40 kg/m2
* Not a resident of Saudi Arabia for more than 5 years
* Presence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes