Zevalin Before Stem Cell Transplant in Treating Patients With Non-Hodgkin Lymphoma

NCT ID: NCT01811368

Last Updated: 2022-11-30

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-03-12
• Study Completion Date: 2023-12-31

Brief Summary

This phase II trial studies how well ibritumomab tiuxetan before donor peripheral blood stem cell transplant works in treating patients with relapsed or refractory non-Hodgkin lymphoma. Giving rituximab, antithymocyte globulin, and total-lymphoid irradiation (TLI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells and helps stop the patient's immune system from rejecting the donor's stem cells. Also, radiolabeled monoclonal antibodies, such as ibritumomab tiuxetan, can find cancer cells and carry cancer-killing substances to them without harming normal cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving rituximab, antithymocyte globulin, and TLI before the transplant together with cyclosporine and mycophenolate mofetil after the transplant may stop this from happening. Giving a radiolabeled monoclonal antibody before a donor peripheral blood stem cell transplant may be an effective treatment for non-Hodgkin lymphoma.

Detailed Description

PRIMARY OBJECTIVES:

I. To measure the response conversion (progressive disease [PD]/stable disease [SD] to partial response [PR] and complete response [CR]).

SECONDARY OBJECTIVES:

I. To assess the time to engraftment/chimerism. II. To assess the rate of acute and chronic graft-versus-host disease (GVHD). III. To assess toxicity. IV. To determine the overall survival. V. To investigate immune functional and phenotypic analysis. VI. To measure two year event free survival (EFS).

OUTLINE:

CONDITIONING REGIMEN: Patients receive rituximab intravenously (IV) on days -21 and 14, ibritumomab tiuxetan IV on day -14, TLI on days -11 to -7 and -4 to -1, and antithymocyte globulin IV over 4-6 hours on days -11 to -7. Patients also undergo TLI on days -11 to -7 and -4 to -1.

TRANSPLANT: Patients undergo allogeneic peripheral blood stem cell transplant (PBSCT) on day 0.

GVHD PROPHYLAXIS: Patients receive cyclosporine orally (PO) twice daily (BID) or IV on days -3 to 56 with taper to 6 months and mycophenolate mofetil PO BID or IV on days 0-28.

After completion of study treatment, patients are followed up periodically.

Conditions

Refractory Non Hodgkin Lymphoma; Relapsed Non Hodgkin Lymphoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment (ibritumomab tiuxetan, allogeneic PBSCT)

CONDITIONING REGIMEN: Patients receive rituximab IV on days -21 and 14, ibritumomab tiuxetan IV on day -14, TLI on days -11 to -7 and -4 to -1, and antithymocyte globulin IV over 4-6 hours on days -11 to -7. Patients also undergo TLI on days -11 to -7 and -4 to -1.

TRANSPLANT: Patients undergo allogeneic PBSCT on day 0.

GVHD PROPHYLAXIS: Patients receive cyclosporine PO BID or IV on days -3 to 56 with taper to 6 months and mycophenolate mofetil PO BID or IV on days 0-28.

Group Type: EXPERIMENTAL

rituximab

Intervention Type: BIOLOGICAL

Given IV

ibritumomab tiuxetan

Intervention Type: BIOLOGICAL

Given IV

anti-thymocyte globulin

Intervention Type: BIOLOGICAL

Given IV

total nodal irradiation

Intervention Type: RADIATION

Undergo TLI

peripheral blood stem cell transplantation

Intervention Type: PROCEDURE

Undergo allogeneic peripheral blood stem cell transplant

allogeneic hematopoietic stem cell transplantation

Intervention Type: PROCEDURE

Undergo allogeneic peripheral blood stem cell transplant

cyclosporine

Intervention Type: DRUG

Given PO or IV

mycophenolate mofetil

Intervention Type: DRUG

Given PO or IV

Interventions

rituximab

Given IV

Intervention Type: BIOLOGICAL

ibritumomab tiuxetan

Given IV

Intervention Type: BIOLOGICAL

anti-thymocyte globulin

Given IV

Intervention Type: BIOLOGICAL

total nodal irradiation

Undergo TLI

Intervention Type: RADIATION

peripheral blood stem cell transplantation

Undergo allogeneic peripheral blood stem cell transplant

Intervention Type: PROCEDURE

allogeneic hematopoietic stem cell transplantation

Undergo allogeneic peripheral blood stem cell transplant

Intervention Type: PROCEDURE

cyclosporine

Given PO or IV

Intervention Type: DRUG

mycophenolate mofetil

Given PO or IV

Intervention Type: DRUG

Other Intervention Names

IDEC-C2B8; Mabthera; Rituxan; Zevalin; ATG; ATGAM; lymphocyte immune globulin; Thymoglobulin; TLI; total lymphoid irradiation; PBPC transplantation; PBSC transplantation; peripheral blood progenitor cell transplantation; transplantation, peripheral blood stem cell; cyclosporin; cyclosporin A; CYSP; Sandimmune; Cellcept; MMF

Eligibility Criteria

Inclusion Criteria

• Histologically or cytologically confirmed relapsed cluster of differentiation (CD)20+ non-Hodgkin's lymphoma (NHL) (included in this category are follicular grade I, II, III, marginal zone, mantle cell, diffuse large B cell, small lymphocytic lymphoma) and CD20+ Hodgkin's disease for which standard curative therapy does not exist or is no longer effective
• Patients must have had at least one prior chemotherapeutic regimen; steroids alone and local radiation do not count as regimens; radiotherapy must have been completed at least 4 weeks prior to entry into the study; Rituxan alone does not count as a regimen; however, Bexxar or Zevalin (ibritumomab tiuxetan) do and patients must have completed radioimmunotherapy (RIT) > 12 months prior to enrollment
• Karnofsky performance status of ≥ 60%
• Life expectancy of greater than 3 months
• Total bilirubin within institutional normal limits
• Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 times institutional upper limit of normal
• Creatinine within normal institutional limits OR creatinine clearance >= 60 ml/min/1.73 m^2 for patients with creatinine levels above institutional normal
• Blood counts no restrictions
• Patients who had anything less than a CR (PR, SD or progressive disease) to their last salvage regimen
• Ability to understand and the willingness to sign a written informed consent document
• Patients fit for non-myeloablative transplantation or best treatment that have an available matched (9/10 or better) related or unrelated donor
• Patients who are considered rituximab refractory (defined as progression within 6 months of their last rituximab-containing regimen)

Exclusion Criteria

• Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study, rituximab within three months (unless there is evidence of progression), or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier are excluded; this does not include the use of steroids which may continue until two days prior to enrollment
• Patients may not be receiving any other investigational agents
• Failure to obtain insurance/payment authorization for Zevalin, unless the subject agrees to cover the cost
• Patients with known active brain metastases, other neurological disorders/dysfunction or a history of seizure disorder, or other neurological dysfunction should be excluded from this clinical trial because of their poor prognosis
• Patients who have an uncontrolled infection (presumed or documented) with progression after appropriate therapy for greater than one month
• Patients with symptomatic coronary artery disease, uncontrolled congestive heart failure; left ventricular ejection fraction is not required to be measured, however if it is measured, patient is excluded if ejection fraction is < 30%
• Patients requiring supplementary continuous oxygen; diffusion capacity of the lung of carbon monoxide (DLCO) is not required to be measured, however if it is measured, patient is excluded if DLCO < 35%
• Patients with clinical or laboratory evidence of liver disease will be evaluated for the cause of liver disease, its clinical severity in terms of liver function and histology, and for the degree of portal hypertension
• Patients with any of the following liver function abnormalities will be excluded:

• Fulminant liver failure
• Cirrhosis with evidence of portal hypertension or bridging fibrosis
• Alcoholic hepatitis
• Esophageal varices
• A history of bleeding esophageal varices
• Hepatic encephalopathy
• Uncorrectable hepatic synthetic dysfunction evidenced by prolongation of the prothrombin time
• Ascites related to portal hypertension
• Chronic viral hepatitis with total serum bilirubin > 3 mg/dL
• Symptomatic biliary disease
• Pregnant women are excluded from this study
• Human immunodeficiency virus (HIV)-positive patients

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Spectrum Pharmaceuticals, Inc

INDUSTRY

Sponsor Role: collaborator

Joseph Tuscano

OTHER

Sponsor Role: lead

Responsible Party

Joseph Tuscano

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Joseph Tuscano

Role: PRINCIPAL_INVESTIGATOR

UC Davis Comprehensive Cancer Center

Locations

University of California Davis

Sacramento, California, United States

Countries

United States

Other Identifiers

UCDCC#233

Identifier Type: OTHER

Identifier Source: secondary_id

NCI-2012-02753

Identifier Type: REGISTRY

Identifier Source: secondary_id

367905

Identifier Type: -

Identifier Source: org_study_id