Safety of Ibritumomab Tiuxetan (Zevalin®) in Combination With a Fludarabine-based Reduced Intensity Conditioning (RIC) Regimen (ZEVALLO 2007)

NCT ID: NCT00607854

Last Updated: 2016-10-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 31 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-02-29
• Study Completion Date: 2011-11-30

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of Zevalin® in a Reduced Intensity Conditioning regimen followed by allogenic stem cell support in patients with aggressive lymphomas who are responsive to a salvage chemotherapy regimen.

Detailed Description

The benefit of Zevalin® in the setting of autologous stem cell transplantation has been largely reported. The addition of Zevalin® to a fludarabine-based Reduced Intensity Conditioning regimen has been already evaluated in the setting of allo-SCT and the results reported so far seem to be promising without an overwhelming toxicity neither a delayed hematologic recovery. The assumption that the addition of Zevalin® to the conditioning regimen might improve lymphoma control and the demonstration that nucleoside analogs such as fludarabine synergize optimally with RIT led us to conduct this trial using the following preparative regimen: rituximab 250 mg/m² on days -21 and -14, Zevalin® 0,4 mCi/Kg body weight on day -14, fludarabine 30 mg/m² intravenously from days -6 to -2, Busulfan orally (4 mg/Kg body weight) or intravenously (0,8 mg/Kg body weight) on days -5 and -4 and ATG (Thymoglobulin®) 2,5 mg/Kg body weight intravenously on day -1. Cyclosporine A is administered at 2 or 3 mg/Kg body weight from day -1 to day 28 than followed by a dose reduction.

The purpose of this study is to evaluate the safety and efficacy of Zevalin® in a Reduced Intensity Conditioning regimen followed by allogenic stem cell support in patients with aggressive lymphomas who are responsive to a salvage chemotherapy regimen

Patients are followed from the beginning of the RIC regimen until day 365 for primary and secondary objectives of the study than on a regular basis depending on the practice of each centre. The evaluation includes physical examination (performance status, hematologic assessment, acute and chronic GVH disease), biologic tests (blood screening for blood count, renal and hepatic function, B and T-cell recovery, chimerism analysis, response assessment) and complementary examinations (marrow biopsies, tomography scan, positron emission tomography, …).

Conditions

Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Zevalin

Zevalin associated with a Fludarabine-based reduced-intensity conditioning regimen,all patients will receive Zevalin in the conditioning regimen

Group Type: EXPERIMENTAL

Ibritumomab Tiuxetan (Zevalin)

Intervention Type: DRUG

Conditioning regimen followed by allogeneic hematopoietic stem cell transplantation.

Ibritumomab Tiuxetan(Zevalin): 0.4 mCi/kg IV at day -14 (Day 0 is the transplantation)

Interventions

Ibritumomab Tiuxetan (Zevalin)

Conditioning regimen followed by allogeneic hematopoietic stem cell transplantation.

Ibritumomab Tiuxetan(Zevalin): 0.4 mCi/kg IV at day -14 (Day 0 is the transplantation)

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age ≥ 18 and ≤ 65
• Patients with this lymphoma:

1. CD20 positive diffuse large B-cell lymphoma in relapse or refractory after two prior regimens or after one regimen including autologous stem cell transplantation, or

2. CD20 positive mantle-cell lymphoma in relapse or refractory after two prior regimens or after one regimen including autologous stem cell transplantation or

3. Other CD20 positive aggressive lymphoma for which an indication of allograft is selected (Burkitt lymphoma, lymphoblastic lymphoma, intra-vascular lymphoma…..) or

4. Low grade lymphoma CD20 positive (follicular lymphoma, marginal zone lymphoma) in histological processing or

5. Low grade lymphoma CD20 positive for which an indication of allograft is selected

• And sensitive to relapse's treatment
• HLA-matched related or unrelated donor 10/10 or 9/10 with C or DQ mismatch without contra-indication for stem cell mobilization
• ECOG (Eastern Cooperative Oncology Group) < 2
• Having or not received previously rituximab
• With a chemosensitive relapse NHL (at least partial response > 50% as defined with cheson criteria (See appendix 5)
• Eligible for an allogenic transplant
• With a signed informed consent (obtained on the screening day at the latest and before any investigation)
• Patient affiliated to or beneficiary of the National Health Service

Exclusion Criteria

• Patient allografted previously
• History of cancer
• Patient with HIV or HCV positive serology and requiring treatment
• Childbearing or child breastfeeding women
• Women who are pregnant or nursing, or man, in the absence of effective contraception during treatment and up to 12 months after stopping treatment
• Any contraindication to allogenic stem cell transplantation:
• Cardiac insufficiency (ejection fraction < 50% by echocardiography)
• Respiratory insufficiency defined as DLCO below 50% of the theoretical value
• Renal failure defined as creatinin clearance < 30 ml/mn
• Hepatic failure defined as a 2-fold increase of bilirubin or transaminases except if due to the lymphoma
• Known hypersensitivity to murine antibodies and other proteins, the active ingredients or any of the ingredients of the products under review
• Patient under the protection of justice

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Bayer

INDUSTRY

Sponsor Role: collaborator

University Hospital, Bordeaux

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Krimo BOUABDALLAH, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Bordeaux, France

Geneviève CHENE, Pr

Role: STUDY_CHAIR

University Hospital Bordeaux, France

Locations

Service d'hématologie - CHU de Besançon

Besançon, , France

Service des maladies du sang - Hôpital Haut-Lévêque - avenue de magellan

Bordeaux - Pessac, , France

Service d'hématologie - CHU Hôtel Dieu Clermont-Ferrand

Clermont-Ferrand, , France

Service de médecine nucléaire - Centre de Lutte contre le Cancer de la Région Auvergne Jean Perrin

Clermont-Ferrand, , France

Hôpital Edouard Herriot

Lyon, , France

Service d'Oncologie Hématologie, Institut Paoli Calmettes - 232 Bd Ste Marguerite

Marseille, , France

Hématologie et Oncologie médicale - CHU Lapeyronie

Montpellier, , France

Service d'Hématologie, Hôpital Hôtel Dieu, CHU Nantes - 1 Place Alexis Ricordeau

Nantes, , France

Service d'hématologie clinique - Hôpital l'Archet 1

Nice, , France

Service d'Hématologie Adultes - Hôpital Necker-Enfants Malade

Paris, , France

Pôle hématologie et immunologie clinique - Hôpital Saint-Louis

Paris, , France

Département d'hématologie et d'Oncologie - CHRU Hautepierre

Strasbourg, , France

Countries

France

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Other Identifiers

CHUBX 2007/11

Identifier Type: -

Identifier Source: org_study_id