Effects of Supplementation With Linseed Oil on Blood Lipids in Vegetarians

NCT ID: NCT01788917

Last Updated: 2022-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2009-12-31

Brief Summary

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The study was performed to investigate the effects of a daily consumption of linseed oil on fatty acid distribution in plasma and red blood cell lipids and blood lipids in vegetarians.

Detailed Description

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Recent studies suggest that the daily intake of n-3 LC-PUFA (EPA and DHA) can modulate cardiovascular risk factors and prevent lifestyle diseases.

The major dietary source of EPA and DHA is seafood (seaweeds and fatty cold water fishes), but they can also be found in lean red meat, in organ meats such as liver and brain. Vegetarians who do not eat meat or fish, have very low or negligible intakes of EPA (\< 5 mg EPA/d) and DHA.

The purpose of the present study is to explore the tissue distribution and inter-conversion of ALA to n-3 LC-PUFA as consequence of linseed oil supplementation in vegetarians.

Eight vegetarians (3 m; 5 f) who do not eat meat, fish or seaweeds such as algae foods since least two years ago and two subjects (1 m; 1w) who consume the normal western style diet living in Jena (Germany) entered the study. The participants consumed 10 mL linseed oil per day for 10 weeks. The resulting daily dose of ALA was approx. 5.7 g/d.

Conditions

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Inter-conversion n-3 PUFA, Vegetarians

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vegetarians

Dietary supplement: 10 mL linseed oil per day

Group Type EXPERIMENTAL

Linseed oil

Intervention Type DIETARY_SUPPLEMENT

Dietary supplement: 10 mL linseed oil per day

Omnivores

Dietary supplement: 10 mL linseed oil per day

Group Type PLACEBO_COMPARATOR

Linseed oil

Intervention Type DIETARY_SUPPLEMENT

Dietary supplement: 10 mL linseed oil per day

Interventions

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Linseed oil

Dietary supplement: 10 mL linseed oil per day

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* for the vegetarian sub-group : vegetarian diet pattern

Exclusion Criteria

* high performance sport, daily alcohol intake and the in-take of dietary supplements (e.g., fish oil capsules)
* for the vegetarian sub-group, the consumption of fish and algae products (e.g. seaweeds, sushi)
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Jena

OTHER

Sponsor Role lead

Responsible Party

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Gerhard Jahreis

Professor Dr. G. Jahreis

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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H39_09

Identifier Type: -

Identifier Source: org_study_id

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