An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction
NCT ID: NCT01787110
Last Updated: 2017-12-11
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
PHASE3
Total Enrollment
6629 participants
Study Classification
INTERVENTIONAL
Study Start Date
2013-04-30
Study Completion Date
2016-12-30
Brief Summary
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The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is manifested in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world.
However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data is conflicting and failing to clarify the role of supplemental oxygen in AMI.
The DETO2X-AMI trial is designed to shed light on this important issue.
However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data is conflicting and failing to clarify the role of supplemental oxygen in AMI.
The DETO2X-AMI trial is designed to shed light on this important issue.
Detailed Description
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AIM:
The aim of the DETO2X-AMI trial is to evaluate the role of supplemental oxygen delivery in the setting of acute coronary syndrome myocardial infarction including ST-segment elevation myocardial infarction (STEMI), non ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA).
DESIGN:
DETO2X-AMI is a multicentre, interventional, controlled, randomized registry based clinical trial (RRCT) recruiting 6600 patients at cardiac care facilities which report into the SWEDEHEART registry throughout the whole of Sweden.
The SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) registry is a nationwide used platform allowing a broad population of all-comers access to the broad registry network which includes:
* RIKS-HIA (nationwide registry where all ischemia cases treated on cardiac intensive care units are registered),
* SCAAR (Swedish Coronary Angiography and Angioplasty Registry where nationwide all coronary angiography and percutaneous coronary intervention (PCI) procedures are registered))
* SEPHIA (nationwide registry for all post AMI follow-up in patients below 75 years of age).
All follow-up will be carried out in SWEDEHEART and other national registries such as the national cause of death register (dödsorsaksregister) or the national patient register (slutenvårdsregister). A similar set-up has been successfully used for the TASTE (Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia) trial.
MATERIAL and METHODS:
Patients with normal oxygen saturation (≥90% on pulse oximeter) presenting to the ambulance service or the emergency department (ED) with classical symptoms suggestive of acute coronary syndrome (ACS) and significant ECG changes or elevated cardiac biomarkers (ED) are evaluated for inclusion. If eligible, oral informed consent is obtained by EMD or ED personnel prior to inclusion. Randomization is carried out on the cardiac intensive care unit using a web-based tool as part of registration directly into the national SWEDEHEART registry.
Patients are randomized to either supplemental oxygen delivered by oxymask® (6 L/min) for 12 hours (min 6 hours) or no supplemental O₂. All patients receive standard care according to international ACS guidelines including acute coronary intervention.
EFFICACY OUTCOMES:
Primary efficacy outcome
All-cause mortality at one year in all patients with suspected AMI (ITT).
Secondary efficacy outcomes
In the ITT population and AMI cohort:
* MACE 1: composite of all-cause mortality or rehospitalization with heart failure\*
* MACE 2: composite of all-cause mortality or rehospitalization with heart failure or readmission with myocardial infarction
* rehospitalization with heart failure
* rehospitalization with AMI
* rehospitalization with shock (Kilip ≥3)\*
* cardiovascular death \*
* health economy
In the STEMI cohort: MACE as a composite of all-cause death, rehospitalization with MI, cardiogenic shock, or stent thrombosis\* plus as above.
\*These outcomes were specified after the trial had started, but before any treatment comparisons were available.
Primary and secondary outcomes will be assessed at 30 days and one year of follow up. Supplementary per-protocol analysis will be performed.
Subgroup analyses consist of predefined subgroups including gender, age, AMI/Non-AMI, Type-I AMI ( STEMI/NSTEMI), smokers, Hb, oxygen saturation levels, patients with chronic obstructive pulmonary disease, chronic kidney disease and diabetes mellitus.
Two main sub studies will be performed:
DETO2X-Biomarkers, a multicenter sub study to the DETO2X-AMI trial assessing if oxygen treatment enhances oxidative stress, systemic inflammation, and markers of apoptosis and MMPs in ACS patients, thereby potentially increasing myocardial damage and cell death, and potentially the prognosis (see separate trial protocol or clinicaltrials.gov NCT02290080 for details).
DETO2X-OXYPAIN 2, a multicenter sub study to the DETO2X-AMI trial at centers with catheter laboratories evaluating a possible analgesic effect of oxygen in using visual-analog scale (VAS).
Follow-up is carried out according to clinical post AMI routine which includes a standardized registration in the SWEDEHEART registry. Mortality data is obtained from the national cause of death register which is linked to SWEDEHEART.
CONCLUSION:
There is no conclusive evidence from adequately designed and powered trials supporting the routine administration of supplemental oxygen in the setting of suspected AMI. The DETO2X-AMI trial is designed to shed light on this important issue and give guidance to future recommendations.
The aim of the DETO2X-AMI trial is to evaluate the role of supplemental oxygen delivery in the setting of acute coronary syndrome myocardial infarction including ST-segment elevation myocardial infarction (STEMI), non ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA).
DESIGN:
DETO2X-AMI is a multicentre, interventional, controlled, randomized registry based clinical trial (RRCT) recruiting 6600 patients at cardiac care facilities which report into the SWEDEHEART registry throughout the whole of Sweden.
The SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) registry is a nationwide used platform allowing a broad population of all-comers access to the broad registry network which includes:
* RIKS-HIA (nationwide registry where all ischemia cases treated on cardiac intensive care units are registered),
* SCAAR (Swedish Coronary Angiography and Angioplasty Registry where nationwide all coronary angiography and percutaneous coronary intervention (PCI) procedures are registered))
* SEPHIA (nationwide registry for all post AMI follow-up in patients below 75 years of age).
All follow-up will be carried out in SWEDEHEART and other national registries such as the national cause of death register (dödsorsaksregister) or the national patient register (slutenvårdsregister). A similar set-up has been successfully used for the TASTE (Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia) trial.
MATERIAL and METHODS:
Patients with normal oxygen saturation (≥90% on pulse oximeter) presenting to the ambulance service or the emergency department (ED) with classical symptoms suggestive of acute coronary syndrome (ACS) and significant ECG changes or elevated cardiac biomarkers (ED) are evaluated for inclusion. If eligible, oral informed consent is obtained by EMD or ED personnel prior to inclusion. Randomization is carried out on the cardiac intensive care unit using a web-based tool as part of registration directly into the national SWEDEHEART registry.
Patients are randomized to either supplemental oxygen delivered by oxymask® (6 L/min) for 12 hours (min 6 hours) or no supplemental O₂. All patients receive standard care according to international ACS guidelines including acute coronary intervention.
EFFICACY OUTCOMES:
Primary efficacy outcome
All-cause mortality at one year in all patients with suspected AMI (ITT).
Secondary efficacy outcomes
In the ITT population and AMI cohort:
* MACE 1: composite of all-cause mortality or rehospitalization with heart failure\*
* MACE 2: composite of all-cause mortality or rehospitalization with heart failure or readmission with myocardial infarction
* rehospitalization with heart failure
* rehospitalization with AMI
* rehospitalization with shock (Kilip ≥3)\*
* cardiovascular death \*
* health economy
In the STEMI cohort: MACE as a composite of all-cause death, rehospitalization with MI, cardiogenic shock, or stent thrombosis\* plus as above.
\*These outcomes were specified after the trial had started, but before any treatment comparisons were available.
Primary and secondary outcomes will be assessed at 30 days and one year of follow up. Supplementary per-protocol analysis will be performed.
Subgroup analyses consist of predefined subgroups including gender, age, AMI/Non-AMI, Type-I AMI ( STEMI/NSTEMI), smokers, Hb, oxygen saturation levels, patients with chronic obstructive pulmonary disease, chronic kidney disease and diabetes mellitus.
Two main sub studies will be performed:
DETO2X-Biomarkers, a multicenter sub study to the DETO2X-AMI trial assessing if oxygen treatment enhances oxidative stress, systemic inflammation, and markers of apoptosis and MMPs in ACS patients, thereby potentially increasing myocardial damage and cell death, and potentially the prognosis (see separate trial protocol or clinicaltrials.gov NCT02290080 for details).
DETO2X-OXYPAIN 2, a multicenter sub study to the DETO2X-AMI trial at centers with catheter laboratories evaluating a possible analgesic effect of oxygen in using visual-analog scale (VAS).
Follow-up is carried out according to clinical post AMI routine which includes a standardized registration in the SWEDEHEART registry. Mortality data is obtained from the national cause of death register which is linked to SWEDEHEART.
CONCLUSION:
There is no conclusive evidence from adequately designed and powered trials supporting the routine administration of supplemental oxygen in the setting of suspected AMI. The DETO2X-AMI trial is designed to shed light on this important issue and give guidance to future recommendations.
Conditions
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Acute Coronary Syndrome
Non-ST Elevation (NSTEMI) Myocardial Infarction
Acute ST Segment Elevation Myocardial Infarction
Angina, Unstable
Keywords
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Acute coronary syndrome
Acute myocardial infarction
Non ST-segment Myocardial Infarction
ST-segment Myocardial Infarction
STEMI
NSTEMI
Oxygen
Unstable angina
Randomised trial
CMR
Mortality
RCRT
RRCT
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
NONE
Study Groups
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No oxygen
For patients randomised to withholding oxygen treatment
* no oxygen is administered at any time as long as the oxygen saturation is ≥90% on pulse oximeter (repetitive checks are performed)
* all patients receive standard acute coronary syndrome treatment including reperfusion strategies
* observation duration 12 hours
Group Type
NO_INTERVENTION
No interventions assigned to this group
Oxygen
For patients randomised to oxygen therapy:
* 6 L/min of oxygen delivered by oxymask® started immediately after inclusion of the ambulance service or in the emergency department given continuously for 6-12 hours (at least 6 hours)
* all patients receive standard acute coronary syndrome treatment including reperfusion strategies
Group Type
ACTIVE_COMPARATOR
Oxygen
Intervention Type
DRUG
see arm description
Interventions
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Oxygen
see arm description
Intervention Type
DRUG
Eligibility Criteria
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Inclusion Criteria
* symptoms (chest pain, dyspnea) indicating acute myocardial ischemia within the last 6 hours
* ECG changes (ST-segment elevation ≥ 2 mm V1-V4, or ≥ 1 mm in other leads, ST-segment depression \>1 mm in any lead, negative T-wave in leads V2-V6, pathological Q-wave in at least 2 adjacent leads), left bundle branch block
and/or elevated levels of cardiac troponin levels in the ED
indicating acute myocardial ischemia
* oxygen saturation ≥90% (pulse oximeter)
* age ≥30
* ECG changes (ST-segment elevation ≥ 2 mm V1-V4, or ≥ 1 mm in other leads, ST-segment depression \>1 mm in any lead, negative T-wave in leads V2-V6, pathological Q-wave in at least 2 adjacent leads), left bundle branch block
and/or elevated levels of cardiac troponin levels in the ED
indicating acute myocardial ischemia
* oxygen saturation ≥90% (pulse oximeter)
* age ≥30
Exclusion Criteria
* unwillingness to participate
* inability to comprehend given information
* continuous oxygen delivery at home prior to inclusion
* cardiac arrest prior to inclusion
* inability to comprehend given information
* continuous oxygen delivery at home prior to inclusion
* cardiac arrest prior to inclusion
Minimum Eligible Age
30 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Swedish Heart Lung Foundation
OTHER
Sponsor Role
collaborator
Swedish Foundation for Strategic Research
OTHER
Sponsor Role
collaborator
The Swedish Research Council
OTHER_GOV
Sponsor Role
collaborator
Karolinska Institutet
OTHER
Sponsor Role
lead
Responsible Party
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Leif Svensson
Professor of Cardiology
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Leif Svensson, MD, PHD
Role: STUDY_DIRECTOR
Karolinska Institutet
Locations
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Enköping Hospital
Enköping, , Sweden
Site Status
Gävle Hospital
Gävle, , Sweden
Site Status
Gothenburg University Hospital, Sahlgrenska
Gothenburg, , Sweden
Site Status
Gothenburg University Hospital, Östra
Gothenburg, , Sweden
Site Status
Hallands Hospital Halmstad
Halmstad, , Sweden
Site Status
Ryhov Hospital Jönköping
Jönköping, , Sweden
Site Status
Kalmar Regional Hospital
Kalmar, , Sweden
Site Status
Karlstad Hospital
Karlstad, , Sweden
Site Status
Kiruna Hospital
Kiruna, , Sweden
Site Status
Köping Hospital
Köping, , Sweden
Site Status
Kristianstad Hospital
Kristianstad, , Sweden
Site Status
Skaraborgs Hospital Lidköping
Lidköping, , Sweden
Site Status
Linköping University Hospital
Linköping, , Sweden
Site Status
Skåne University Hospital Lund
Lund, , Sweden
Site Status
Skåne University Hospital Malmö
Malmo, , Sweden
Site Status
Sahlgrenska Universitetssjukhus Mölndal
Mölndal, , Sweden
Site Status
Vrinnevi Hospital Norrköping
Norrköping, , Sweden
Site Status
Norrtälje Hospital
Norrtälje, , Sweden
Site Status
Nyköping Hospital
Nyköping, , Sweden
Site Status
Örebro University Hospital
Örebro, , Sweden
Site Status
Örnsköldsvik Hospital
Örnsköldsvik, , Sweden
Site Status
Östersund Hospital
Östersund, , Sweden
Site Status
Skaraborgs Hospital Skövde
Skövde, , Sweden
Site Status
St: Göran Hospital
Stockholm, , Sweden
Site Status
Södersjukhuset
Stockholm, , Sweden
Site Status
Karolinska University Hospital Huddinge
Stockholm, , Sweden
Site Status
Karolinska University Hospital Solna
Stockholm, , Sweden
Site Status
Danderyds Sjukhus
Stockholm, , Sweden
Site Status
Härnosand Hospital Sundsvall
Sundsvall, , Sweden
Site Status
Trelleborg Hospital
Trelleborg, , Sweden
Site Status
Norrlands University Hospital
Umeå, , Sweden
Site Status
Uppsala University Hospital
Uppsala, , Sweden
Site Status
Hallands Hospital Varberg
Varberg, , Sweden
Site Status
Växjö Hospital
Vaxjo, , Sweden
Site Status
Countries
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Sweden
References
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Rawles JM, Kenmure AC. Controlled trial of oxygen in uncomplicated myocardial infarction. Br Med J. 1976 May 8;1(6018):1121-3. doi: 10.1136/bmj.1.6018.1121.
Reference Type
BACKGROUND
Farquhar H, Weatherall M, Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Beasley R. Systematic review of studies of the effect of hyperoxia on coronary blood flow. Am Heart J. 2009 Sep;158(3):371-7. doi: 10.1016/j.ahj.2009.05.037. Epub 2009 Jul 15.
Reference Type
BACKGROUND
Ranchord AM, Argyle R, Beynon R, Perrin K, Sharma V, Weatherall M, Simmonds M, Heatlie G, Brooks N, Beasley R. High-concentration versus titrated oxygen therapy in ST-elevation myocardial infarction: a pilot randomized controlled trial. Am Heart J. 2012 Feb;163(2):168-75. doi: 10.1016/j.ahj.2011.10.013. Epub 2012 Jan 13.
Reference Type
BACKGROUND
Ukholkina GB, Kostianov IIu, Kuchkina NV, Grendo EP, Gofman IaB. [Effect of oxygenotherapy used in combination with reperfusion in patients with acute myocardial infarction]. Kardiologiia. 2005;45(5):59. No abstract available. Russian.
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BACKGROUND
Moradkhan R, Sinoway LI. Revisiting the role of oxygen therapy in cardiac patients. J Am Coll Cardiol. 2010 Sep 21;56(13):1013-6. doi: 10.1016/j.jacc.2010.04.052.
Reference Type
BACKGROUND
Cabello JB, Burls A, Emparanza JI, Bayliss S, Quinn T. Oxygen therapy for acute myocardial infarction. Cochrane Database Syst Rev. 2010 Jun 16;(6):CD007160. doi: 10.1002/14651858.CD007160.pub2.
Reference Type
BACKGROUND
Burls A, Cabello JB, Emparanza JI, Bayliss S, Quinn T. Oxygen therapy for acute myocardial infarction: a systematic review and meta-analysis. Emerg Med J. 2011 Nov;28(11):917-23. doi: 10.1136/emj.2010.103564. Epub 2011 Feb 23.
Reference Type
BACKGROUND
Frobert O, Lagerqvist B, Gudnason T, Thuesen L, Svensson R, Olivecrona GK, James SK. Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia (TASTE trial). A multicenter, prospective, randomized, controlled clinical registry trial based on the Swedish angiography and angioplasty registry (SCAAR) platform. Study design and rationale. Am Heart J. 2010 Dec;160(6):1042-8. doi: 10.1016/j.ahj.2010.08.040.
Reference Type
BACKGROUND
Kones R. Oxygen therapy for acute myocardial infarction-then and now. A century of uncertainty. Am J Med. 2011 Nov;124(11):1000-5. doi: 10.1016/j.amjmed.2011.04.034.
Reference Type
BACKGROUND
Shuvy M, Atar D, Gabriel Steg P, Halvorsen S, Jolly S, Yusuf S, Lotan C. Oxygen therapy in acute coronary syndrome: are the benefits worth the risk? Eur Heart J. 2013 Jun;34(22):1630-5. doi: 10.1093/eurheartj/eht110. Epub 2013 Apr 3.
Reference Type
BACKGROUND
Stub D, Smith K, Bernard S, Bray JE, Stephenson M, Cameron P, Meredith I, Kaye DM; AVOID Study. A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen In myocarDial infarction study (AVOID Study). Am Heart J. 2012 Mar;163(3):339-345.e1. doi: 10.1016/j.ahj.2011.11.011.
Reference Type
BACKGROUND
Hofmann R, James SK, Svensson L, Witt N, Frick M, Lindahl B, Ostlund O, Ekelund U, Erlinge D, Herlitz J, Jernberg T. DETermination of the role of OXygen in suspected Acute Myocardial Infarction trial. Am Heart J. 2014 Mar;167(3):322-8. doi: 10.1016/j.ahj.2013.09.022. Epub 2013 Dec 19.
Reference Type
BACKGROUND
Frobert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T, Maeng M, Aasa M, Angeras O, Calais F, Danielewicz M, Erlinge D, Hellsten L, Jensen U, Johansson AC, Karegren A, Nilsson J, Robertson L, Sandhall L, Sjogren I, Ostlund O, Harnek J, James SK; TASTE Trial. Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med. 2013 Oct 24;369(17):1587-97. doi: 10.1056/NEJMoa1308789. Epub 2013 Aug 31.
Reference Type
BACKGROUND
Stub D, Smith K, Bernard S, Nehme Z, Stephenson M, Bray JE, Cameron P, Barger B, Ellims AH, Taylor AJ, Meredith IT, Kaye DM; AVOID Investigators. Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction. Circulation. 2015 Jun 16;131(24):2143-50. doi: 10.1161/CIRCULATIONAHA.114.014494. Epub 2015 May 22.
Reference Type
BACKGROUND
Bulluck H, Hausenloy DJ. Letter by Bulluck and Hausenloy Regarding Article, "Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction". Circulation. 2016 Jan 19;133(3):e28. doi: 10.1161/CIRCULATIONAHA.115.017968. No abstract available.
Reference Type
BACKGROUND
Nehme Z, Stub D, Bernard S, Stephenson M, Bray JE, Cameron P, Meredith IT, Barger B, Ellims AH, Taylor AJ, Kaye DM, Smith K; AVOID Investigators. Effect of supplemental oxygen exposure on myocardial injury in ST-elevation myocardial infarction. Heart. 2016 Mar;102(6):444-51. doi: 10.1136/heartjnl-2015-308636. Epub 2016 Jan 6.
Reference Type
BACKGROUND
James S, Rao SV, Granger CB. Registry-based randomized clinical trials--a new clinical trial paradigm. Nat Rev Cardiol. 2015 May;12(5):312-6. doi: 10.1038/nrcardio.2015.33. Epub 2015 Mar 17.
Reference Type
BACKGROUND
Nedeljkovic ZS, Jacobs AK. Oxygen for ST-Segment-Elevation Myocardial Infarction: Still Up in the Air. Circulation. 2015 Jun 16;131(24):2101-3. doi: 10.1161/CIRCULATIONAHA.115.017072. Epub 2015 May 22. No abstract available.
Reference Type
BACKGROUND
Sepehrvand N, Ezekowitz JA. Oxygen Therapy in Patients With Acute Heart Failure: Friend or Foe? JACC Heart Fail. 2016 Oct;4(10):783-790. doi: 10.1016/j.jchf.2016.03.026. Epub 2016 Jun 8.
Reference Type
BACKGROUND
Stub D, Smith K, Bernard S, Nehme Z, Stephenson M, Bray JE, Cameron P, Barger B, Ellims AH, Taylor AJ, Meredith IT, Kaye DM. Response to Letter Regarding Article, "Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction". Circulation. 2016 Jan 19;133(3):e29. doi: 10.1161/CIRCULATIONAHA.115.019038. No abstract available.
Reference Type
BACKGROUND
Hofmann R, Abebe TB, Herlitz J, James SK, Erlinge D, Alfredsson J, Jernberg T, Kellerth T, Ravn-Fischer A, Lindahl B, Langenskiold S; DETO2X-SWEDEHEART Investigators. Avoiding Routine Oxygen Therapy in Patients With Myocardial Infarction Saves Significant Expenditure for the Health Care System-Insights From the Randomized DETO2X-AMI Trial. Front Public Health. 2022 Jan 12;9:711222. doi: 10.3389/fpubh.2021.711222. eCollection 2021.
Reference Type
DERIVED
Hofmann R, Befekadu Abebe T, Herlitz J, James SK, Erlinge D, Yndigegn T, Alfredsson J, Kellerth T, Ravn-Fischer A, Volz S, Lauermann J, Jernberg T, Lindahl B, Langenskiold S. Routine Oxygen Therapy Does Not Improve Health-Related Quality of Life in Patients With Acute Myocardial Infarction-Insights From the Randomized DETO2X-AMI Trial. Front Cardiovasc Med. 2021 Mar 15;8:638829. doi: 10.3389/fcvm.2021.638829. eCollection 2021.
Reference Type
DERIVED
Lindahl B, Ljung L, Herlitz J, Alfredsson J, Erlinge D, Kellerth T, Omerovic E, Ravn-Fischer A, Sparv D, Yndigegn T, Svensson P, Ostlund O, Jernberg T, James SK, Hofmann R; DETO2X-SWEDEHEART Investigators. Poor long-term prognosis in patients admitted with strong suspicion of acute myocardial infarction but discharged with another diagnosis. J Intern Med. 2021 Aug;290(2):359-372. doi: 10.1111/joim.13272. Epub 2021 Mar 16.
Reference Type
DERIVED
James SK, Erlinge D, Herlitz J, Alfredsson J, Koul S, Frobert O, Kellerth T, Ravn-Fischer A, Alstrom P, Ostlund O, Jernberg T, Lindahl B, Hofmann R; DETO2X-SWEDEHEART Investigators. Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation. JACC Cardiovasc Interv. 2020 Feb 24;13(4):502-513. doi: 10.1016/j.jcin.2019.09.016. Epub 2019 Dec 11.
Reference Type
DERIVED
Nystrom T, James SK, Lindahl B, Ostlund O, Erlinge D, Herlitz J, Omerovic E, Mellbin L, Alfredsson J, Frobert O, Jernberg T, Hofmann R; DETO2X-SWEDEHEART Investigators. Oxygen Therapy in Myocardial Infarction Patients With or Without Diabetes: A Predefined Subgroup Analysis From the DETO2X-AMI Trial. Diabetes Care. 2019 Nov;42(11):2032-2041. doi: 10.2337/dc19-0590. Epub 2019 Aug 31.
Reference Type
DERIVED
Jernberg T, Lindahl B, Alfredsson J, Berglund E, Bergstrom O, Engstrom A, Erlinge D, Herlitz J, Jumatate R, Kellerth T, Lauermann J, Lindmark K, Lingman M, Ljung L, Nilsson C, Omerovic E, Pernow J, Ravn-Fischer A, Sparv D, Yndigegn T, Ostlund O, James SK, Hofmann R; DETO2X-SWEDEHEART Investigators. Long-Term Effects of Oxygen Therapy on Death or Hospitalization for Heart Failure in Patients With Suspected Acute Myocardial Infarction. Circulation. 2018 Dec 11;138(24):2754-2762. doi: 10.1161/CIRCULATIONAHA.118.036220.
Reference Type
DERIVED
Hofmann R, James SK, Jernberg T, Lindahl B, Erlinge D, Witt N, Arefalk G, Frick M, Alfredsson J, Nilsson L, Ravn-Fischer A, Omerovic E, Kellerth T, Sparv D, Ekelund U, Linder R, Ekstrom M, Lauermann J, Haaga U, Pernow J, Ostlund O, Herlitz J, Svensson L; DETO2X-SWEDEHEART Investigators. Oxygen Therapy in Suspected Acute Myocardial Infarction. N Engl J Med. 2017 Sep 28;377(13):1240-1249. doi: 10.1056/NEJMoa1706222. Epub 2017 Aug 28.
Reference Type
DERIVED
Related Links
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http://www.deto2x.se
Click here for more information about this study
Other Identifiers
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DETO2X-AMI 2012/287-12
Identifier Type: -
Identifier Source: org_study_id