Testogel® (Testosterone Gel 50mg/5g) in the Treatment of Male Hypogonadism

NCT ID: NCT01786473

Last Updated: 2013-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of Testogel® 50mg/5g gel administered once daily (QD, morning dosing) compared to placebo administered once daily (QD, morning dosing), for 3 months, in hypogonadal men with testosterone deficiency being confirmed by clinical features and biochemical tests. For men with hypogonadism, treatment aims to restore testosterone levels to normal physiological range.

Detailed Description

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Conditions

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Hypogonadism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Testogel 1% 5g QD

Group Type EXPERIMENTAL

Testogel 1%

Intervention Type DRUG

Placebo gel 5g QD

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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Testogel 1%

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male ages 18-68 years diagnosed as having testosterone deficiency with clinical symptoms
* A morning (8:00-10:00) serum Total Testosterone concentration of ≤ 300 ng/dL, confirmed by a second measurement of morning serum Total Testosterone concentration ≤ 300 ng/dL (samples to be taken 1 - 3 weeks apart)

Exclusion Criteria

* Abnormal prostate as evidenced by prostatic symptoms, prostatic masses or induration on rectal examination, or elevated levels of prostate specific antigen (PSA \> 4ng/ml) or a maximum urine flow rate of less than 12 ml/sec(of a urine volume greater than 150ml) (and/or an International Prostate Symptom Score IPSS score \>19)
* Hematocrit \> 50%
* Major psychiatric illness
* Unable to understand the protocol or to give informed consent
* Use of paroxetine and clomipramine
* Active alcoholism
* History of drug abuse within the past five years;
* Use of drugs that might interfere with the results of the study (e.g., antiandrogen, estrogens or P 450 enzyme inducers, barbiturates);
* BMI \< 18 or \> 30 according to Chinese BMI references;
* Generalized skin disease that may affect absorption of T (e.g., psoriasis) or a known skin intolerance to alcohol;
* Prolactin \> 40 mcg/L;
* Untreated severe obstructive sleep apnea;.
* Uncontrolled or poorly controlled heart failure
Minimum Eligible Age

18 Years

Maximum Eligible Age

68 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Laboratoires Besins International

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jie Jin

Role: PRINCIPAL_INVESTIGATOR

Peking University First Hospital

Locations

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Peking University First Hospital

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ellen Dhoore

Role: CONTACT

Other Identifiers

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01BHR11

Identifier Type: -

Identifier Source: org_study_id

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