Efficacy and Safety of Testogel® in Men With Partial Androgen Deficiency of Aging Males (PADAM)

NCT ID: NCT00185198

Last Updated: 2014-04-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

363 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-09-30

Study Completion Date

2007-10-31

Brief Summary

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The purpose of this study is to investigate the effect of a testosterone replacement therapy called Testogel in men with PADAM. The effects on body composition (lean, fat and bone) and other symptoms of PADAM and safety will be studied.

Detailed Description

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The study has previously been posted by Schering AG, Germany. Schering AG, Germany has been renamed to Bayer Schering Pharma AG, Germany.

Bayer Schering Pharma AG, Germany is the sponsor of the trial.

Conditions

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Androgens (Deficiency) Male

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Arm 1

Group Type ACTIVE_COMPARATOR

Testogel (Testosterone, BAYV001915)

Intervention Type DRUG

50mg (5g gel sachet), 75mg (5g+2.5g sachet) or 100mg (2x5g sachet) per day applied to the skin of the shoulders, arms or abdomen for 18 months

Arm 2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

5g gel sachet, 5g+2.5g sachet or 2x5g sachets per day applied to the skin of the shoulders, arms or abdomen for 6 months followed by 12 months treatment with testosterone 1% gel as described for arm 1

Interventions

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Testogel (Testosterone, BAYV001915)

50mg (5g gel sachet), 75mg (5g+2.5g sachet) or 100mg (2x5g sachet) per day applied to the skin of the shoulders, arms or abdomen for 18 months

Intervention Type DRUG

Placebo

5g gel sachet, 5g+2.5g sachet or 2x5g sachets per day applied to the skin of the shoulders, arms or abdomen for 6 months followed by 12 months treatment with testosterone 1% gel as described for arm 1

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Symptomatic hypogonadism
* Willing to avoid significant change in the pattern of physical exercise and lifestyle for the duration of the study

Exclusion Criteria

* Patients with any contraindication for testosterone use
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Vienna, Vienna, Austria

Site Status

Graz, , Austria

Site Status

Innsbruck, , Austria

Site Status

Salzburg, , Austria

Site Status

Vienna, , Austria

Site Status

Helsinki, , Finland

Site Status

Oulu, , Finland

Site Status

Tampere, , Finland

Site Status

Bonn, North Rhine-Westphalia, Germany

Site Status

Dresden, Saxony, Germany

Site Status

Leipzig, Saxony, Germany

Site Status

Halle, Saxony-Anhalt, Germany

Site Status

Magdeburg, , Germany

Site Status

Dublin, , Ireland

Site Status

Milan, , Italy

Site Status

Napoli, , Italy

Site Status

Roma, , Italy

Site Status

Roma, , Italy

Site Status

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status

Madrid, Madrid, Spain

Site Status

Barcelona, , Spain

Site Status

Gothenburg, , Sweden

Site Status

Malmo, , Sweden

Site Status

Stockholm, , Sweden

Site Status

Reading, Berkshire, United Kingdom

Site Status

Wigan, Manchester, United Kingdom

Site Status

Cardiff, , United Kingdom

Site Status

London, , United Kingdom

Site Status

London, , United Kingdom

Site Status

Sheffield, , United Kingdom

Site Status

Countries

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Austria Finland Germany Ireland Italy Spain Sweden United Kingdom

Other Identifiers

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2004-001545-15

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

307720

Identifier Type: OTHER

Identifier Source: secondary_id

91297

Identifier Type: -

Identifier Source: org_study_id

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