Study Results
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Basic Information
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WITHDRAWN
PHASE4
INTERVENTIONAL
2012-12-31
2013-02-28
Brief Summary
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Pulsed electromagnetic field (PEMF) devices have been shown to be effective treatments to decrease healing time in nonunion fractures and pressure ulcers, and to reduce pain in whiplash injuries, persistent neck pain, and chronic lower back pain. These devices have been FDA approved for treatment of pain and edema (510(k) number: K070541). More recently, PEMF devices have been shown to decrease postoperative pain and narcotic use in breast augmentation patients. This study seeks to determine if PEMF will also cause similar effects in the more complex procedures performed on body contouring patients. The specific aims of this study are:
1. Evaluate if adjunct PEMF therapy will accelerate the rate of postoperative pain reduction in abdominal body contouring patients.
2. Evaluate if adjunct PEMF therapy will decrease the postoperative use of narcotic pain relievers in abdominal body contouring patients.
PEMF devices have been shown to be effective in reduction of pain and pain medication use in breast augmentation patients. No literature has shown if PEMF is an effective adjunct to decrease pain or pain medication use in the abdominal body contouring patient. A decrease in pain would result in a better experience for patients and a reduction in pain medication may decrease complications associated with these medications. The PEMF therapy device being used in this study is a non-significant risk device because it is noninvasive and does not present a potential for serious risk to the health, safety, or welfare of a subject.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Active Device
Device Placement:
Upon completion of the subjects' standard of care body contouring surgery, the device will be placed directly on the operative dressings within an unobtrusive binder with Velcro strips and will be activated before the subject leaves the OR. Subjects will then be educated on the functionality and interpretation of the user interface of the device. They will be educated on the application, removal, and return of the device.
Active Devices The device will be activated at the time of placement. The active devices are programmed to automatically deliver treatment. Each treatment duration is 15 minutes. The active device delivers treatment every 2 hours. A light will flash on the device when the PEMF begins and will continue to flash every second until the end of the treatment. Between treatments the device will be in "sleep mode" and the light will flash every 5 seconds.
Active Device (IVIVI SofPulse)
Sham Device
Device Placement:
Upon completion of the subjects' standard of care body contouring surgery, the device will be placed directly on the operative dressings within an unobtrusive binder with velcro strips and will be activated before the subject leaves the OR. Subjects will then be educated on the functionality and interpretation of the user interface of the device. They will be educated on the application, removal, and return of the device.
Sham Devices The sham devices mirror the active device with the exception of the delivery of the PEMF. The sham device will be "activated" at the time of placement. A light will flash on the device when the SHAM PEMF begins and will continue to flash every second until the end each treatment interval. While in "sleep mode" the device will not deliver treatment and the light will flash every 5 seconds.
Sham Device
Interventions
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Active Device (IVIVI SofPulse)
Sham Device
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Eligible for and have agreed to be scheduled for elective abdominal body contouring surgery
* Willing and able to comply with all study procedures.
Exclusion Criteria
* Patients having multiple procedures concurrently except liposuction.
* Current use of oral steroids as determined through patient history and medical record review
* Current narcotic use as determined through patient history or medical record review
* Current nerve or pain disorder.
* Recent (1 month) coronary stent or implanted medical device (e.g. pacemaker).
* Pregnancy (demonstrated by a positive result of a urine pregnancy test)
* Based upon surgeon judgement and the results of screening procedures, patient is not a suitable candidate for surgery.
18 Years
ALL
No
Sponsors
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University of Pittsburgh
OTHER
Responsible Party
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J. Peter Rubin, MD
Principal Investigator
Principal Investigators
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J. Peter Rubin, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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UPMC Center for Innovation in Restorative Medicine
Pittsburgh, Pennsylvania, United States
Countries
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References
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Greco JA 3rd, Castaldo ET, Nanney LB, Wendel JJ, Summitt JB, Kelly KJ, Braun SA, Hagan KF, Shack RB. The effect of weight loss surgery and body mass index on wound complications after abdominal contouring operations. Ann Plast Surg. 2008 Sep;61(3):235-42. doi: 10.1097/SAP.0b013e318166d351.
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Liboff AR, Cherng S, Jenrow KA, Bull A. Calmodulin-dependent cyclic nucleotide phosphodiesterase activity is altered by 20 microT magnetostatic fields. Bioelectromagnetics. 2003 Jan;24(1):32-8. doi: 10.1002/bem.10063.
Korhonen R, Lahti A, Kankaanranta H, Moilanen E. Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):471-9. doi: 10.2174/1568010054526359.
Reale M, De Lutiis MA, Patruno A, Speranza L, Felaco M, Grilli A, Macri MA, Comani S, Conti P, Di Luzio S. Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field. Nitric Oxide. 2006 Aug;15(1):50-7. doi: 10.1016/j.niox.2005.11.010. Epub 2006 Feb 7.
Jeong JH, Kum C, Choi HJ, Park ES, Sohn UD. Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis. Life Sci. 2006 Feb 23;78(13):1407-12. doi: 10.1016/j.lfs.2005.07.006. Epub 2006 Feb 7.
Fitzsimmons RJ, Gordon SL, Kronberg J, Ganey T, Pilla AA. A pulsing electric field (PEF) increases human chondrocyte proliferation through a transduction pathway involving nitric oxide signaling. J Orthop Res. 2008 Jun;26(6):854-9. doi: 10.1002/jor.20590.
Pilla AA, Nasser PR, Kaufman JJ. Gap junction impedance, tissue dielectrics and thermal noise limits for electromagnetic field bioeffects. Bioelectrochem Bioenerg (1994) 35:63-69
Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, Pilla AA. Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model. J Hand Surg Am. 2006 Sep;31(7):1131-5. doi: 10.1016/j.jhsa.2006.03.024.
Strauch B, Patel MK, Navarro JA, Berdichevsky M, Yu HL, Pilla AA. Pulsed magnetic fields accelerate cutaneous wound healing in rats. Plast Reconstr Surg. 2007 Aug;120(2):425-430. doi: 10.1097/01.prs.0000267700.15452.d0.
Roland D, Ferder M, Kothuru R, Faierman T, Strauch B. Effects of pulsed magnetic energy on a microsurgically transferred vessel. Plast Reconstr Surg. 2000 Apr;105(4):1371-4. doi: 10.1097/00006534-200004040-00016.
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Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, Simon BJ, Gurtner GC. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg. 2008 Jan;121(1):130-141. doi: 10.1097/01.prs.0000293761.27219.84.
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Stiller MJ, Pak GH, Shupack JL, Thaler S, Kenny C, Jondreau L. A portable pulsed electromagnetic field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double-blind, placebo-controlled clinical trial. Br J Dermatol. 1992 Aug;127(2):147-54. doi: 10.1111/j.1365-2133.1992.tb08047.x.
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Other Identifiers
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PRO12070504
Identifier Type: -
Identifier Source: org_study_id
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