Intragastric Balloon for Treatment of Non Alcoholic Steatohepatitis (NASH)

NCT ID: NCT01761370

Last Updated: 2013-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Study Completion Date

2008-09-30

Brief Summary

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The study will determine the feasibility of using Bioenteric intragastric balloon (BIB) in the treatment of patients with Non alcoholic Steatohepatitis (NASH).

Detailed Description

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The Bio-enteric Intra-gastric balloon (BIB) has been shown to be an effective treatment for weight reduction in obese patients. This study will determine the feasibility of using BIB in the treatment of patients with Non alcoholic Steatohepatitis (NASH). It will evaluate the efficacy of the BIB in improving histology of NASH in obese patients.

Conditions

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Non Alcoholic Steatohepatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Treatment

AHA diet plus exercise with BIB placement

Group Type ACTIVE_COMPARATOR

AHA diet plus exercise with BIB placement

Intervention Type PROCEDURE

AHA diet plus exercise with BIB placement for 6 months

Sham control

AHA diet plus exercise with sham BIB placement

Group Type SHAM_COMPARATOR

AHA diet plus exercise with sham BIB placement

Intervention Type PROCEDURE

AHA diet plus exercise with sham BIB placement

Interventions

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AHA diet plus exercise with BIB placement

AHA diet plus exercise with BIB placement for 6 months

Intervention Type PROCEDURE

AHA diet plus exercise with sham BIB placement

AHA diet plus exercise with sham BIB placement

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients between 21-65 years of age,
* Had histological evidence of NASH,
* Had a BMI of greater than 27kg/m2, and
* Had failed at least 6 month trial of medical therapy for weight reduction.

Exclusion Criteria

* Patients with any organic disease of the upper GI tract,
* Were receiving anti-inflammatory drugs,
* Anticoagulants or steroids, or
* Had a history of alcoholism or drug addiction. A hiatus hernia of \> 5 cm, an active gastric or duodenal ulcer, and prior or intestinal surgery were considered contraindications to the placement of BIB.
Minimum Eligible Age

21 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National University Hospital, Singapore

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yin Mei Lee, MBChB

Role: PRINCIPAL_INVESTIGATOR

National University Hospital, Singapore

Locations

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National University Hospital

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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D/05/338

Identifier Type: -

Identifier Source: org_study_id

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