Antipsychotic Discontinuation in High-risk Subjects

NCT ID: NCT01758887

Last Updated: 2016-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2016-09-30

Brief Summary

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* Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control?
* What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis?
* What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?

Detailed Description

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After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers

Conditions

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Schizophrenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Controls

Healthy control

No interventions assigned to this group

patients

clinical high risk subjects for psychosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosed as a clinical High Risk
* Treated with antipsychotic drugs
* PSP1-5 (from SIPS criteria) \<3 (severity index)for more than 6 months
* Had not experienced a symptomatic relapse in the 6 months

Exclusion Criteria

* Significant abnormality in laboratory tests
* History of head trauma
Minimum Eligible Age

16 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jun Soo Kwon

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jun Soo Kwon, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University College of Medicine

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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H-1207-055-417

Identifier Type: -

Identifier Source: org_study_id

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