Stem Cell Research on Subjects at Genetic High Risk for Schizophrenia

NCT ID: NCT01943175

Last Updated: 2019-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-30

Study Completion Date

2015-11-30

Brief Summary

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This study aims at finding endophenotypes of schizophrenia at neuronal level by obtaining stem cells which is derived from adipose cells of subjects with heavy genetic loading for schizophrenia then differentiating them into neuronal cells.

Detailed Description

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Conditions

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Genetic High Risk for Schizophrenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Genetic High Risk

No interventions assigned to this group

Healthy Control

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\[Subjects at genetic high risk for schizophrenia\]

* Healthy without any Axis I mental disorder
* Is a monozygotic twin of a patient with schizophrenia OR Has at least two family members of schizophrenia in the pedigree, including at least one 1st-degree family member

\[Healthy Control\]

* Healthy without any Axis I mental disorder
* No family members of schizophrenia in the pedigree to the 3rd degree

Exclusion Criteria

* Significant neurological or medical illness
* Psychotic symptoms
* Substance abuse
* Suicidal risk
* Blindness or hearing loss
* Taking aspirin, warfarin or hormonal agents
* Pregnancy or lactation
* Susceptibility for keloid formation
* Allergy to lidocaine
* History of significant head trauma or loss of consciousness
* Mental retardation
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ministry of Health & Welfare, Korea

OTHER_GOV

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jun Soo Kwon, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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A120476

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

H-1207-117-419

Identifier Type: -

Identifier Source: org_study_id

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