Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

47 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-03

Study Completion Date

2017-10-25

Brief Summary

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Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load. This can be prevented by modifying ventilator settings, using vasopressors or inotropes or even by prone positionning.But to do so, right ventricular dysfonction has to be detected. Echocardiography has emerged as a first line tool to diagnose right heart failure. Recently, strain analysis showed promising results to detect early right ventricle abnormalities in other settings such as pulmonary hypertension or scleroderma. We therefore decided to determine whether 2D strain could help detect early right ventricular dysfunction in ARDS.

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Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome Right Ventricular Dysfunction Right Heart Failure Acute Cor Pulmonale

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ARDS group

Patients under mechanical ventilation since less than 24 hours at inclusion and presenting acute respiratory distress syndrome criteria.

No interventions assigned to this group

ALI group

Patients under mechanical ventilation and presenting acute lung injury criteria.

No interventions assigned to this group

Control Group

Patients under mechanical ventilation for a non-respiratory cause

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Need for mechanical ventilation
* ARDS criteria met: Respiratory failure not fully explained by cardiac failure, Pao2/FiO2\<200, bilateral opacities on Chest imaging, all symptoms appeared within 1 week

* Need for mechanical ventilation
* ALI criteria met: Respiratory failure not fully explained by cardiac failure, Pao2/FiO2\<300, bilateral opacities on Chest imaging, all symptoms appeared within 1 week

* Need for mechanical ventilation for a non-respiratory cause

Exclusion Criteria

* Predictable duration of mechanical ventilation shorter than 48 hours
* Contraindication to transesophageal echocardiography

ALI group:

* Predictable duration of mechanical ventilation shorter than 48 hours

Control Group:

* Need for FiO2\>30%
* Known cardiac abnormalities
* Cardiac drugs intake during last 24 hours

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No